| Identification | Back Directory | [Name]
Bromo-PEG2-acid | [CAS]
1807503-92-9 | [Synonyms]
Br-PEG2-acid
Bromo-PEG2-acid
Bromo-PEG3-acid
CAS_1807503-92-9
Br-PEG2-CH2CH2COOH
Bromo-PEG2-C2-acid
Bromo-PEG2-acid >=95%
Bromo-PEG2-propionic acid
3-(2-(2-Bromoethoxy)ethoxy)propanoic acid
Propanoic acid, 3-[2-(2-bromoethoxy)ethoxy]- | [Molecular Formula]
C7H13BrO4 | [MDL Number]
MFCD28122969 | [MOL File]
1807503-92-9.mol | [Molecular Weight]
241.08 |
| Chemical Properties | Back Directory | [Boiling point ]
347.2±27.0 °C(Predicted) | [density ]
1.464±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Liquid | [pka]
4.27±0.10(Predicted) | [color ]
Light brown to yellow |
| Hazard Information | Back Directory | [Description]
Bromo-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bromo-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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