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ChemicalBook--->CAS DataBase List--->18000-24-3

18000-24-3

18000-24-3 Structure

18000-24-3 Structure
IdentificationMore
[Name]

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
[CAS]

18000-24-3
[Synonyms]

7-CKA
7-CL-KYNA
7-CHLOROKYNURENIC ACID
7-Chloroquinurenic acid
7-Chlorokynurenic acid (7-CKA)
7-CHLOROKYNURENIC ACID HYDROCHLORIDE
7-Chloro-4-hydroxy-2-quinolinecarboxylic acid
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
7-chloro-4-keto-1H-quinoline-2-carboxylic acid
2-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-
7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL
7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA
7-Chloro-4-hydroxyquinoline-2-carboxylic acid hydrochloride
[EINECS(EC#)]

241-913-6
[Molecular Formula]

C10H7Cl2NO3
[MDL Number]

MFCD00674924
[Molecular Weight]

260.07
[MOL File]

18000-24-3.mol
Questions And AnswerBack Directory
[Target]

 Ki: 0.59 μM (reuptake of glutamate)    IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)
Chemical PropertiesBack Directory
[Melting point ]

277-278 °C (decomp)
[Boiling point ]

461.5±45.0 °C(Predicted)
[density ]

1.600±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

0.1 M NaOH: 13.7 mg/mL
[form ]

solid
[pka]

0.90±0.30(Predicted)
[color ]

tan
[CAS DataBase Reference]

18000-24-3(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

NMDA receptor antagonist at the glycine site
[Definition]

ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
[Biological Functions]

Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
[Biological Activity]

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
[in vivo]

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
[storage]

Room temperature
Spectrum DetailBack Directory
[Spectrum Detail]

7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL(18000-24-3)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

18000-24-3(sigmaaldrich)
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