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ChemicalBook--->CAS DataBase List--->1784-03-8

1784-03-8

1784-03-8 Structure

1784-03-8 Structure
IdentificationMore
[Name]

TOS-ARG-OME HCL
[CAS]

1784-03-8
[Synonyms]

ALPHA-N-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
L-TAME
N-ALPHA-4-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
NALPHA-P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
NALPHA-P-TOSYL-L-ARGININE METHYL ESTER HCL
N-ALPHA-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
N-ALPHA-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT
N-ALPHA-TOLUENESULFONYLARGININE METHYL ESTER HYDROCHLORIDE
NALPHA-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
N-ALPHA-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT
N-A-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
N-P-TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL
P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
P-TOSYL-L-ARG METHYL ESTER HCL
TAME
TAME HYDROCHLORIDE
TOS-ARGININE-OME HCL
TOS-ARG-OME HCL
TOSYL-L-ARGININE METHYL ESTER HYDROCHLORIDE
[EINECS(EC#)]

217-235-1
[Molecular Formula]

C14H23ClN4O4S
[MDL Number]

MFCD00012578
[Molecular Weight]

378.87
[MOL File]

1784-03-8.mol
Chemical PropertiesBack Directory
[Appearance]

white fine crystalline powder
[Melting point ]

145-147(lit.)
[alpha ]

-14 º (c=4, H2O)
[refractive index ]

-14 ° (C=4, H2O)
[storage temp. ]

−20°C
[solubility ]

methanol: 50 mg/mL, clear, colorless
[form ]

Fine Crystalline Powder
[color ]

White
[BRN ]

3922357
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
[InChIKey]

JIQFFACVQXXHMY-YDALLXLXSA-N
[CAS DataBase Reference]

1784-03-8(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[WGK Germany ]

3
[F ]

3-10
[HS Code ]

29252900
Hazard InformationBack Directory
[Description]

TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2
[Chemical Properties]

white fine crystalline powder
[Uses]

enzyme inhibitor
[Uses]

N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.
[Uses]

Substrate for trypsin, thrombin, plasmin and other proteases.
[Biochem/physiol Actions]

Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.
[References]

1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382 2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383
Spectrum DetailBack Directory
[Spectrum Detail]

TOS-ARG-OME HCL(1784-03-8)1HNMR
TOS-ARG-OME HCL(1784-03-8)IR
TOS-ARG-OME HCL(1784-03-8)FT-IR
TOS-ARG-OME HCL(1784-03-8)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Nalpha-4-Tosyl-L-arginine methyl ester hydrochloride, 99%(1784-03-8)
[Sigma Aldrich]

1784-03-8(sigmaaldrich)
[TCI AMERICA]

Nalpha-Tosyl-L-arginine Methyl Ester Hydrochloride,>98.0%(T)(1784-03-8)
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