| Identification | More | [Name]
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one | [CAS]
17129-06-5 | [Synonyms]
4-ETHOXY-1,1,1-TRIFLUORO-3-BUTEN-2-ONE
4-ETHOXY-1,1,1-TRIFLUORO-BUT-3-EN-2-ONE
AKOS B022234
ART-CHEM-BB B022234
4-ETHOXY-1,1,1-TRIFLUORO-3-BUTEN-2-ONE, TECH.
4-ethoxy-1,1,1-trifluoro-3-buten-2-on
(3E)-4-Ethoxy-1,1,1-trifluorobut-3-en-2-one
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one, 94%, stab.
(E)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one | [EINECS(EC#)]
629-004-6 | [Molecular Formula]
C6H7F3O2 | [MDL Number]
MFCD00192131 | [Molecular Weight]
168.11 | [MOL File]
17129-06-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
-30℃ | [Boiling point ]
51-53 °C/12 mmHg (lit.) | [density ]
1.18 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.406(lit.)
| [Fp ]
125 °F
| [storage temp. ]
2-8°C | [solubility ]
soluble in Chloroform, Methanol | [form ]
Liquid | [color ]
Colorless to yellow | [Sensitive ]
Moisture Sensitive | [InChIKey]
YKYIFUROKBDHCY-ONEGZZNKSA-N | [LogP]
1.414 (est) | [CAS DataBase Reference]
17129-06-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,F | [Risk Statements ]
R10:Flammable.
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1224 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Flammable/Harmful | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29147000 |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow liquid | [Uses]
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may be used in the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones. It may be used for the synthesis of β-alkyl- or dialkylamino substituted enones bearing a CF3 group. | [General Description]
4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ5-oxaphospholen. It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis. |
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