| Identification | More | [Name]
OLSALAZINE | [CAS]
15722-48-2 | [Synonyms]
OLSALAZINE
3,3’-azobis(6-hydroxy-benzoicaci
3,3’-azobis(6-hydroxybenzoicacid)
5,5’-azobis(salicylicacid)
azodisal
c.i.mordantyellow5
Ph-CJ-91B
4,4'-Dihydroxyazobenzene-3,3'-dicarboxylic acid
5,5'-Azodisalicylic acid | [EINECS(EC#)]
605-089-5 | [Molecular Formula]
C14H10N2O6 | [MDL Number]
MFCD00602469 | [Molecular Weight]
302.24 | [MOL File]
15722-48-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C(Solv: acetic acid (64-19-7); water (7732-18-5)) | [Boiling point ]
443.29°C (rough estimate) | [density ]
1.3578 (rough estimate) | [refractive index ]
1.6500 (estimate) | [form ]
Solid | [pka]
2.40±0.10(Predicted) | [color ]
Light yellow to yellow | [Water Solubility ]
11.49ug/L(25 ºC) | [CAS DataBase Reference]
15722-48-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory (gastrointestinal). | [Definition]
ChEBI: An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease. | [Indications]
Olsalazine is approved for maintenance of remission
of ulcerative colitis, but a commonly reported
side effect is a paradoxical increase in diarrhea. The
U. S. Food and Drug Administration (FDA) has approved
balsalazide disodium (Colazal) as a treatment of
mild to moderately active ulcerative colitis. | [Brand name]
Dipentum (UCB). | [Mechanism of action]
Olsalazine is approved for maintenance of remission
of ulcerative colitis, but a commonly reported
side effect is a paradoxical increase in diarrhea. The
U. S. Food and Drug Administration (FDA) has approved
balsalazide disodium (Colazal) as a treatment of
mild to moderately active ulcerative colitis. | [Veterinary Drugs and Treatments]
Olsalazine is used for treatment of dogs with chronic colitis that either
cannot tolerate the adverse effects associated with sulfasalazine
or the response to sulfasalazine has been ineffective. |
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