| Identification | More | [Name]
Phenetidine | [CAS]
156-43-4 | [Synonyms]
1-AMINO-4-ETHOXYBENZENE
4-AMINOETHOXYBENZENE
4'-AMINOPHENETOL
4-AMINOPHENETOLE
4-ETHOXYANILINE
4-ETHOXYYANILINE
4-PHENETIDINE
AKOS BBS-00003550
P-ETHOXYANILINE
phenetidine
P-PHENETIDINE
4-ethoxy-benzenamin
4-Ethoxybenzenamine
4-ethoxy-Benzenamine
4-Ethoxybenzeneamine
Amino-phenyl ethyl ether
Aniline, p-ethoxy-
Benzenam
Benzenamine, 4-ethoxy-
benzenamine,4-ethoxy- | [EINECS(EC#)]
205-855-5 | [Molecular Formula]
C8H11NO | [MDL Number]
MFCD00007865 | [Molecular Weight]
137.18 | [MOL File]
156-43-4.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
2-5 °C(lit.)
| [Boiling point ]
250 °C(lit.)
| [density ]
1.065 g/mL at 25 °C(lit.)
| [vapor pressure ]
2.93Pa at 25℃ | [refractive index ]
n20/D 1.559(lit.)
| [Fp ]
240 °F
| [storage temp. ]
2-8°C | [solubility ]
20g/l | [form ]
A liquid | [pka]
5.2(at 28℃) | [color ]
Clear Yellow | [PH]
8 (1g/l, H2O, 20℃) | [Stability:]
Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents. | [Water Solubility ]
practically insoluble | [Sensitive ]
Air Sensitive | [Merck ]
14,7228 | [BRN ]
606666 | [Dielectric constant]
7.3（21℃） | [InChIKey]
IMPPGHMHELILKG-UHFFFAOYSA-N | [CAS DataBase Reference]
156-43-4(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Ethoxyaniline(156-43-4) | [EPA Substance Registry System]
156-43-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi,Xn | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R68:Possible risk of irreversible effects.
R43:May cause sensitization by skin contact.
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S46:If swallowed, seek medical advice immediately and show this container or label . | [RIDADR ]
UN 2311 6.1/PG 3
| [WGK Germany ]
1
| [RTECS ]
SI6465500
| [F ]
8-10 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29222200 | [Safety Profile]
Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | [Toxicity]
LD50 orl-rat: 580 mg/kg GISAAA 35(8),28,70 |
| Hazard Information | Back Directory | [General Description]
Colorless to dark red liquid. | [Reactivity Profile]
P-PHENETIDINE(156-43-4) reacts vigorously with powerful oxidizers. | [Air & Water Reactions]
Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water. | [Fire Hazard]
This compound is combustible. | [Chemical Properties]
colourless liquid | [Uses]
A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils. | [Definition]
ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 27, p. 347, 1984 DOI: 10.1021/jm00369a019 |
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