| Identification | More | [Name]
TRIMETHYLACETIC ANHYDRIDE | [CAS]
1538-75-6 | [Synonyms]
2,2-DIMETHYLPROPIONIC ACID ANHYDRIDE
2,2-DIMETHYLPROPIONIC ANHYDRIDE
BIS(TRIMETHYLACETIC) ANHYDRIDE
PIVALIC ANHYDRIDE
TRIMETHYLACETIC ACID ANHYDRIDE
TRIMETHYLACETIC ANHYDRIDE
1,1-Dimethylpropanoic anhydride
2,2-dimethyl-propanoicacianhydride
2,2-Dimethylpropanoicanhydride
Pivalic anydride
Propanoic acid, 2,2-dimethyl-, anhydride
Propanoicacid,2,2-dimethyl-,anhydride
2,2-Dimethylpropionic anhydride, Pivalic anhydride
Bis(2,2-dimethylpropionic acid)anhydride
Bis(2,2-dimethylpropionic)anhydride
Bis(pivalic acid)anhydride
Bis(pivalic)anhydride
Dipivalic anhydride
Pivalic acid anhydride | [EINECS(EC#)]
216-263-1 | [Molecular Formula]
C10H18O3 | [MDL Number]
MFCD00008842 | [Molecular Weight]
186.25 | [MOL File]
1538-75-6.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless liquid | [Boiling point ]
193 °C(lit.)
| [density ]
0.918 g/mL at 25 °C(lit.)
| [vapor pressure ]
62.1Pa at 25℃ | [refractive index ]
n20/D 1.409(lit.)
| [Fp ]
135 °F
| [storage temp. ]
Store at RT. | [solubility ]
Miscible with acetonitrile. | [form ]
Liquid | [color ]
Clear colorless | [Sensitive ]
Moisture Sensitive | [BRN ]
386552 | [InChI]
InChI=1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3 | [InChIKey]
PGZVFRAEAAXREB-UHFFFAOYSA-N | [SMILES]
C(C)(C)(C)C(=O)OC(=O)C(C)(C)C | [LogP]
2.15 | [CAS DataBase Reference]
1538-75-6(CAS DataBase Reference) | [EPA Substance Registry System]
Propanoic acid, 2,2-dimethyl-, anhydride (1538-75-6) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2920 8/PG 2
| [WGK Germany ]
3
| [F ]
9-13-21 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29159000 |
| Hazard Information | Back Directory | [Description]
Trimethylacetic anhydride is a pivalic acid derivative that is used in organic synthesis. The compound's reaction mechanism is believed to be the formation of an alkanoic acid, which reacts with a hydroxyl group to form an anhydride. Trimethyl acetic anhydride has been shown to have pharmacokinetic properties and can be used as a nonsteroidal anti-inflammatory drug. This compound has also been found to have a matrix effect on crystalline cellulose and is capable of forming nitrogen-containing carboxylic acids. | [Chemical Properties]
clear colourless liquid | [Uses]
Trimethylacetic anhydride was used:
- in solid-phase oligonucleotide synthesis
- in kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acid
- as acylation and esterification reagent for anilines
- as acylation and esterification reagent for phenols
| [Uses]
A metabolite of a double prodrug (6-dGCV-DPiv | [Flammability and Explosibility]
Notclassified |
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