| Identification | More | [Name]
ENDOTHAL | [CAS]
145-73-3 | [Synonyms]
3,6-EPOXYCYCLOHEXANE-1,2-DICARBOXYLIC ACID
7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC ACID
ACCELERATE
Disodium 3，6-endoxohexahydrophthalate
ENDOTHAL
ENDOTHALL
HERBICIDE 273
1,2-Benzenedicarboxylic acid, hexahydro-3,6-endo-oxy-
1,2-Cyclohexanedicarboxylic acid, 3,6-endo-epoxy-
3,6-endo-epoxy-2-cyclohexanedicarboxylicacid
3,6-endo-Oxohexahydrophthalic acid
3,6-endooxohexahydrophthalicacid
3,6-endo-Oxyphthalic acid hexahydro-
3,6-Endoxohexahydrophthalic acid
3,6-endoxohexahydrophthalicacid
Aquathol
aquatholplus
aquatholplusgranular
Endothal technical
Endothal weed killer | [EINECS(EC#)]
205-660-5 | [Molecular Formula]
C8H10O5 | [MDL Number]
MFCD00137362 | [Molecular Weight]
186.16 | [MOL File]
145-73-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Endothall, when pure, is a white crystalline
solid. The technical grade is a light brown liquid | [Melting point ]
179-180℃ | [Boiling point ]
447.8±40.0 °C(Predicted) | [density ]
1.431 g/cm3 | [storage temp. ]
+2C to +8C | [solubility ]
DMF: 15 mg/ml,DMSO: 15 mg/ml,Ethanol: 15 mg/ml,PBS (pH 7.2): 0.2 mg/ml | [form ]
White solid | [pka]
3.62±0.40(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in water (>25 mg/ml), methanol, acetone, and DMSO. Insoluble in benzene. | [Stability:]
Hygroscopic | [Uses]
Defoliant, herbicide. | [CAS DataBase Reference]
145-73-3(CAS DataBase Reference) | [EPA Substance Registry System]
Endothall (145-73-3) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R21:Harmful in contact with skin.
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
1
| [RTECS ]
RN7875000
| [HazardClass ]
6.1(a) | [PackingGroup ]
II | [Safety Profile]
Poison by ingestion.
Very irritating to skin, eyes, and mucous
membranes. Causes dlarrhea. When heatedto decomposition it emits acrid smoke and
fumes | [Hazardous Substances Data]
145-73-3(Hazardous Substances Data) | [Toxicity]
LD50 in adult male, female rats (mg/kg): 57, 46 orally (Gaines, Linder) |
| Hazard Information | Back Directory | [General Description]
The monohydrate is in the form of colorless crystals. Non corrosive. Used as a selective herbicide. | [Reactivity Profile]
A phthalic acid derivative. | [Air & Water Reactions]
Stable up to 90°C, above which ENDOTHALL(145-73-3) undergoes slow hydrolysis. | [Hazard]
Strong irritant to eyes and skin. | [Potential Exposure]
Endothall is dicarboxylic acid defoliant and herbicide used on both terrestrial and aquatic
weeds. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration
with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with running
water for at least 20 minutes. For minor skin contact, avoid
spreading material on unaffected skin. Keep victim warm
and quiet. Effects of exposure (inhalation, ingestion, or skin
contact) to substance may be delayed. Ensure that medical
personnel are aware of the material(s) involved and take
precautions to protect themselves. Medical observation is
recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for
pulmonary edema, a doctor or authorized paramedic may
consider administering a drug or other inhalation therapy.
| [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials, Technical Name Required. | [Incompatibilities]
Compounds of the carboxyl group react
with all bases, both inorganic and organic (i.e., amines)
releasing substantial heat, water and a salt that may be
harmful. Incompatible with arsenic compounds (releases
hydrogen cyanide gas), diazo compounds, dithiocarbamates,
isocyanates, mercaptans, nitrides, and sulfides (releasing
heat, toxic, and possibly flammable gases), thiosulfates and
dithionites (releasing hydrogen sulfate and oxides of sulfur) | [Chemical Properties]
Endothall, when pure, is a white crystalline
solid. The technical grade is a light brown liquid | [Waste Disposal]
Small quantities may be disposed of by burial in soil which is rich in organic matter.
Large quantities are best disposed of by incineration.
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste
containing this contaminant (5100 kg/mo) must conform
with EPA regulations governing storage, transportation,
treatment, and waste disposal. In accordance with
40CFR165, follow recommendations for the disposal of
pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting
your local or federal environmental control agency, or by
contacting your regional EPA office | [Agricultural Uses]
Herbicide, Algaecide: Endothall is used as a cotton defoliant and as a selective
contact herbicide on both terrestrial and aquatic
weeds. The potassium and amine salts of endothall are
used as aquatic herbicides to control a variety of plants
including plankton, pondweed, niad, coontail, milfoil, elodea,
and algaes in water bodies and rice fields. Endothall
is also used to control annual grass and broadleaf weeds
in sugar beets, spinach and turf. It reduces sucker branch
growth in hops. Endothall is a desiccant to aid the harvest
of alfalfa, potatoes, clover, and cotton. Not approved for
use in EU countries. Approved for use in the U.S. and
other countries. There are 24 global suppliers. | [Trade name]
ACCELERATE®; AQUATHOL®;
DES-I-CATE®; HYDOUT®; HYDROTHAL-47®;
HYDROTHOL®; NIAGARATHOL®; RIPENTHOL®;
TRI-ENDOTHAL® | [Environmental Fate]
Biological. Incubation of 14C-ring labeled endothall (10 mg/mL) by Arthrobacter sp.,
which was isolated from pond water and a hydrosol, in aerobic sediment-water suspensions
revealed that after 30 days, 40% evolved as 14CO2. Glutamic acid was the major transformation
product. Minor products were alanine, citric and aspartic acids and unidentified
products, some of which were tentatively identified as phosphate esters (Sikka and Saxena,
1973). In pond water treated with endothall (2 and 4 ppm), detectable levels were found
after 7 days (Sikka and Rice, 1973). Biodegradation was rapid in an Ontario soil sample.
After 1 week, 70% of endothall added was converted to carbon dioxide (Simsiman et al.,
1976).
Chemical/Physical. Reacts with bases forming water-soluble salts. Above 90°C, endothall
is slowly converted to the anhydride (Windholz et al., 1983; Hartley and Kidd, 1987)
and water (Humburg et al., 1989). Endothall is stable to light (Hartley and Kidd, 1987). |
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