成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->1448428-04-3

1448428-04-3

1448428-04-3 Structure

1448428-04-3 Structure
IdentificationBack Directory
[Name]

Selonsertib
[CAS]

1448428-04-3
[Synonyms]

GS 4997
GS-4497
CS-2217
Selonsertib
GS-4997;ASK-1
GS4997;GS 4997
GS4997 SELONSERTIB
Selonsertib GS-4997
Selonsertib free base.
Selonsertib (Synonyms: GS-4997)
GS-4997; GS4997; GS 4997; SELONSERTIB FREE BASE.
5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide
5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]benzamide
Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-
[Molecular Formula]

C24H24FN7O
[MDL Number]

MFCD29920355
[MOL File]

1448428-04-3.mol
[Molecular Weight]

445.49
Chemical PropertiesBack Directory
[Melting point ]

>180°C (dec.)
[density ]

1.39±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

Soluble in DMSO (>25 mg/ml)
[form ]

solid
[pka]

11.21±0.70(Predicted)
[color ]

White
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
[InChIKey]

YIDDLAAKOYYGJG-UHFFFAOYSA-N
[SMILES]

C(NC1=NC(C2N(C(C)C)C=NN=2)=CC=C1)(=O)C1=CC(N2C=NC(C3CC3)=C2)=C(C)C=C1F
[CAS DataBase Reference]

1448428-04-3
Hazard InformationBack Directory
[Description]

Selonsertib (1448428-04-3) is a potent Apoptosis signal-regulating kinase 1 (ASK1) inhibitor (pIC50 = 8.3)1 found to improve metabolic parameters in nonalcoholic steatohepatitis, reduce hepatic steatosis, inflammation, and fibrosis2-4. Selonsertib suppressed the efflux function of multidrug resistance (MDR) transporters ABCB1 and ABCG2.5
[Uses]

Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Selonsertib interacts with the catalytic kinase domain of ASK1 and prevents its phosphorylation and activation. As a result, the expression of genes involved in fibrosis, cellular proliferation, and apoptosis are down regulated.
[in vitro]

gs-4997 has been identified as a highly selective and potent ask1 inhibitor that competed with atp in the ask1 catalytic kinase domain. moreover, the ask1 inhibition caused by gs-4997 was found to be significantly different in mechanism from bardoxolone methyl. gs- 4997 could also shut down cell signaling involved in pathogenesis, while bardoxolone methyl activated mrna transcription in every cell exposed to drug. in addition, gs-4997 could selectively target affected cells in which the oxidative burden was high [1].
[storage]

Store at -20°C
[References]

Lanier et al. (2017), Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure; ACS Med. Chem. Lett. 8 316 Loomba et al. (2017), The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial; Hepatology 67 549 Younossi et al. (2018), Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib; Liver Int. 38 1849 Gawrieh and Chalasani (2018), Emerging Treatments for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis; Clin. Liver Dis. 22 189 Ji et al. (2019), Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells; Cancer Lett. 440-441 82
Spectrum DetailBack Directory
[Spectrum Detail]

Selonsertib(1448428-04-3)1HNMR
1448428-04-3 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Zhejiang ZETian Fine Chemicals Co. LTD
Tel: +8618957127338 , +8618957127338
Website: www.zetchem.com/
Company Name: Shochem(Shanghai) Co.,Ltd
Tel: 86-21-50800795
Website: www.shochem.com
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Chemia Biotechnology(Shanghai) Co., Ltd
Tel: +8613816753574 , +8613816753574
Website: www.chemia-pharm.com
Company Name: Shenzhen Shengda Pharma Limited
Tel: 755-85269922 +8613424394241 , +8613424394241
Website: www.shengdapharm.com
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471 , +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418684 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Coresyn Pharmatech Co., Ltd.
Tel: +86-571-86626709 +86-18157142896 , +86-18157142896
Website: http://www.coresyn.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Tags:1448428-04-3 Related Product Information
1301761-96-5 1025821-33-3 1014691-61-2 1353625-73-6 101574-65-6 941685-37-6 2152628-33-4 477600-75-2 1382979-44-3 1456632-40-8 1421373-66-1 1403254-99-8 1038915-60-4 139504-50-0 1268524-70-4 1446502-11-9 1448347-49-6 1445993-26-9