| Identification | Back Directory | [Name]
VU 0463271 | [CAS]
1391737-01-1 | [Synonyms]
VU 0463271
N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Acetamide, N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-
VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide)
VU0463271 (Synonyms: N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) | [Molecular Formula]
C19H18N4OS2 | [MDL Number]
MFCD30182240 | [MOL File]
1391737-01-1.mol | [Molecular Weight]
382.5 |
| Hazard Information | Back Directory | [Uses]
VU 0463271 is a novel antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2). | [Biological Activity]
VU0463271 is a potent and selective potassium-chloride cotransporter 2 (KCC2) inhibitor th at displays greatly enhanced potency than its structural analogs VU0255011 (ML077) & VU0240511 (IC50 = 61537and 568 nMrespectively). VU0463271 exhibits much reduced efficacy against the related Na-K-2Cl cotransporter 1 (NKCC1 inhibition max ~37% at 100 μM) and little affinity toward a panel of 68 GPCRsion channelsand transporters. Although VU0463271 is reported to exhibit affinity toward mitochondrial translocator protein TSPO (IC50 of 204 nM against PK11195 binding; r at heart) and inhibitory potency against α1B adrenergic receptor (IC50 of 364.7 nM; human α1B CHO transfectants)these proteins are not known to affect chloride homeostasis. | [storage]
Store at +4°C |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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