| Identification | Back Directory | [Name]
VU 0360172 | [CAS]
1309976-62-2 | [Synonyms]
VU 0360172
VU0360172.HCl
VU 0360172 hydrochloride
N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride
VU0360172 Hydrochloride N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide | [Molecular Formula]
C18H16ClFN2O | [MOL File]
1309976-62-2.mol | [Molecular Weight]
330.79 |
| Hazard Information | Back Directory | [Uses]
VU 0360172 is a an allosteric modulator for mGluR5. Displays efficacy in regulating CNS function in human embryonic kidney cell, rat cortical astrocyte and similar antipsychotic activity in rats. | [Biological Activity]
VU0360172 is a potent (EC50 = 16.6 nM)systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic modelproducing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce absence seizures in WAG/Rij rats and to inhibit pain. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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