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ChemicalBook--->CAS DataBase List--->1374639-75-4

1374639-75-4

1374639-75-4 Structure

1374639-75-4 Structure
IdentificationBack Directory
[Name]

LEE011 (succinate)
[CAS]

1374639-75-4
[Synonyms]

LEE011 (succinate)
Ribociclib succite
Ribociclib succinate
Ribociclib Succinate (Kisqali)
RIBOCICLIB SUCCINATE (LEE011 SUCCINATE)
LEE-011 succinate salt, Ribociclib succinate salt
7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate
[Molecular Formula]

C27H36N8O5
[MOL File]

1374639-75-4.mol
[Molecular Weight]

552.64
Chemical PropertiesBack Directory
[Melting point ]

>160oC (dec.)
[storage temp. ]

Refrigerator
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

Pale Beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS06,GHS08,GHS09
[Signal word ]

Danger
[Hazard statements ]

H301-H315-H319-H372-H400
[Precautionary statements ]

P273-P301+P310-P305+P351+P338-P314
Hazard InformationBack Directory
[Uses]

LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
Spectrum DetailBack Directory
[Spectrum Detail]

LEE011 (succinate)(1374639-75-4)1HNMR
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