| Identification | More | [Name]
Hydrocortisone-17-butyrate | [CAS]
13609-67-1 | [Synonyms]
11b,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate
11BETA,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 17-BUTYRATE
CORTISOL 17-BUTYRATE
HYDROCORTISONE 17-BUTYRATE
HYDROCORTISONE BUTYRATE
11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione17-alpha-butyrate
h.17b
hb(sub17)
hydrocortisone17-alpha-butyrate
locoid
Hydrocortisone Butyrate USP
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11.beta.)-
11β,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate
4-Pregnene-11β,21-dihydroxy-17α-butyryloxy-3,20-dione
Alfason
Butyric acid, 17-ester with cortisol (8CI)
Cortisol, 17-butyrate (6CI, 8CI)
Laticort
Plancol
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11β)- | [EINECS(EC#)]
237-093-4 | [Molecular Formula]
C25H36O6 | [MDL Number]
MFCD00083364 | [Molecular Weight]
432.55 | [MOL File]
13609-67-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
210.0 to 214.0 °C | [Boiling point ]
466.2°C (rough estimate) | [density ]
1.0914 (rough estimate) | [refractive index ]
1.4593 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
12.98±0.10(Predicted) | [color ]
White to Off-White | [Merck ]
14,4787 | [Contact allergens]
Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti-
sone. It represents the D2 group of corticosteroids, non
C 16 methylated with a C 17 ester: hydrocortisone
17-butyrate, hydrocortisone 17-valerate, hydrocortisone
aceponate (17-propionate and 21-acetate), methylpred-
nisolone aceponate, and prednicarbate. It is sometimes
hydrolyzed in vivo into hydrocortisone, giving allergic
reactions to group-A-sensitized people. | [InChIKey]
BMCQMVFGOVHVNG-IZBZUILHNA-N | [SMILES]
O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO)C(=O)CCC |&1:1,4,6,16,18,20,23,r| | [CAS DataBase Reference]
13609-67-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
antineoplastic | [Uses]
Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent. | [Definition]
ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group. | [Brand name]
Locoid (Ferndale); Locoid (Yamanouchi). | [Biochem/physiol Actions]
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck. | [storage]
Store at -20°C |
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