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ChemicalBook--->CAS DataBase List--->1347760-82-0

1347760-82-0

1347760-82-0 Structure

1347760-82-0 Structure
IdentificationBack Directory
[Name]

propargyl-PEG3-Acid
[CAS]

1347760-82-0
[Synonyms]

1347760-82-0
Alkyne-PEG3-COOH
propargyl-PEG3-Acid
PROPARGYL-PEG3-COOH
Propargyl-PEG2-COOH
Propyne-PEG2-CH2CH2COOH
Propargyl-PEG2-CH2CH2COOH
Propargyl-PEG4-(CH2)3-acid
Propargyl-PEG3-Carboxylic Acid
3-[2-[2-(2-Propargyloxy)ethoxy]ethoxy]propanoic Acid
3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid
3-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoic acid
Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
[Molecular Formula]

C10H16O5
[MDL Number]

MFCD22201521
[MOL File]

1347760-82-0.mol
[Molecular Weight]

216.231
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

Soluble in Water, DMSO, DCM, DMF
[form ]

clear liquid
[color ]

Light yellow to Brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H315
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
[HS Code ]

2918.99.5000
Hazard InformationBack Directory
[Description]

Propargyl-PEG3-acid is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.
[Uses]

Propargyl-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
[reaction suitability]

reagent type: linker
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