| Identification | Back Directory | [Name]
Propargyl-PEG4-acid | [CAS]
1415800-32-6 | [Synonyms]
1415800-32-6
Alkyne-PEG4-COOH
PROPARGYL-PEG4-COOH
Propargyl-PEG4-acid
Propargyl-PEG4-CH2CO2H
Propyne-PEG3-CH2CH2COOH
Propargyl-PEG3-CH2CH2COOH
4,7,10,13-tetraoxahexadec-15-ynoic acid | [Molecular Formula]
C12H20O6 | [MDL Number]
MFCD22683284 | [MOL File]
1415800-32-6.mol | [Molecular Weight]
260.28 |
| Chemical Properties | Back Directory | [Boiling point ]
388.0±37.0 °C(Predicted) | [density ]
1.129±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Viscous Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-acid is a PEG reagent with an alkyne and a terminal carboxylic acid. The carboxylic acid reacts with primary amine groups with the help of activators (e.g. EDC, or HATU). The 4-unit PEG spacer increases hydrophilicity. The alkyne can participate in copper-catalyzed Click Chemistry. | [Uses]
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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