| Identification | More | [Name]
AG 490 | [CAS]
134036-52-5 | [Synonyms]
2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE
A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMAMIDE
A-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
AG 490
ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE
(E)-2-CYANO-3-(3,4-DIHYDROPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE
N-BENZYL-3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE
N-BENZYL-3,4-DIHYDROXY-BENZYLIDENECYANOACETAMIDE
TYROPHOSTIN AG490
TYRPHOSTIN AG 490
TYRPHOSTIN B42
TYRPHOSTIN AG 490, 99+%
2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide
N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C17H14N2O3 | [MDL Number]
MFCD00209833 | [Molecular Weight]
294.3 | [MOL File]
134036-52-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow-Green Crystal | [Melting point ]
215 | [Boiling point ]
615.2±55.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
ethanol: 5 mg/mL
| [form ]
solid
| [pka]
8.82±0.35(Predicted) | [color ]
yellow
| [Usage]
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not si | [CAS DataBase Reference]
134036-52-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
1
| [Hazard Note ]
Irritant/Keep Cold under-20C | [HS Code ]
2926907090 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow-Green Crystal | [Uses]
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo. | [Uses]
Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. | [Definition]
ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide. |
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