| Identification | More | [Name]
6,6'-Ureylene-bis(1-naphthol-3-sulfonic acid) | [CAS]
134-47-4 | [Synonyms]
4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid)
6,6'-ureylene-bis(1-naphthol-3-sulfonic acid)
7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid]
phosgenated
N,N'-bis(4-hydroxy-2-sulfonaphthalene-7-yl)urea
7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid)
N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea
2-Naphthalenesulfonic acid, 7,7-(carbonyldiimino)bis4-hydroxy-
J ACID UREA, FREE ACID
66UREYLENEBIS1NAPHTHOL3SULPHONICACIDDISODIUMSALT
7,7'-(carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic aci
6,6'-ureylenbis-1-naphthol-3-sulfonic acid
7,7'-(Carbonylbisimino)bis(4-hydroxynaphthalene-2-sulfonic acid) | [EINECS(EC#)]
205-142-9 | [Molecular Formula]
C21H16N2O9S2 | [MDL Number]
MFCD00035715 | [Molecular Weight]
504.49 | [MOL File]
134-47-4.mol |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sodium bisulfite-->Sodium metabisulfite | [Preparation Products]
Direct Red 23-->Direct Orange S-->Copper, 2,2'-[carbonylbis[imino(1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis[benzoic acid] complex-->trisodium [mu-[2-[[1-hydroxy-6-[[[[5-hydroxy-6-[(2-hydroxy-5-sulphophenyl)azo]-7-sulpho-2-naphthyl]amino]carbonyl]amino]-3-sulpho-2-naphthyl]azo]benzoato(7-)]]dicuprate(3-)-->tetrasodium [mu-[[7,7'-(carbonyldiimino)bis[4-hydroxy-3-[(2-hydroxy-5-sulphophenyl)azo]naphthalene-2-sulphonato]](8-)]]dicuprate(4-)-->Leather Black-->DIRECT ORANGE 118-->DIRECT RED 26-->7,7'-(Carbonyldiimino)bis[4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]-2-naphthalenesulfonic acid]disodium salt-->DIRECT ORANGE 26-->DIRECT RED 4-->trisodium [mu-[2-[[1-hydroxy-6-[[[[5-hydroxy-6-[(2-hydroxy-5-sulphophenyl)azo]-7-sulpho-2-naphthyl]amino]carbonyl]amino]-3-sulpho-2-naphthyl]azo]benzoato(7-)]]dicuprate(3-)-->Direct Violet 89-->Direct red 72-->C.I. Direct Red 36, tetrasodium salt-->Direct Red 264-->DIRECT RED 80-->Direct red 194 (C.I. 35785)-->7,7'-[Ureylenebis[(1-hydroxy-3-sodiosulfonaphthalene-6,2-diyl)azo(4,1-phenylene)azo]]bis[naphthalene-1,3-disulfonic acid disodium] salt-->Direct Red 23 |
| Hazard Information | Back Directory | [Uses]
7,7''-(Carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonic acid) (cas# 134-47-4) is a pharmacologically active compound capable of selective nonbisphosphonate inhibition of human geranylgeranyl diphosphate synthase, and inhibition of shikimate dehydrogenase and shikimate kinase in shikimate pathway of Helicobacter pylori. | [Preparation]
7,7' -Urylenebis(4-hydroxynaphthalene-2- sulfonic acid) [134-47-4] , J acid urea, carbonyl J acid, is produced by reacting the sodium salt of J acid with phosgene in aqueous solution at 30℃ and maintaining alkalinity with sodium carbonate. After being heated to 80℃, the product is salted out with sodium chloride (yield ca. 100 %). It is used to produce C.I. Direct Orange 26; C.I. Direct Reds 4, 14, 23, and 80; and C.I. Direct Brown 112. | [in vivo]
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo[4].
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model[4].
AMI-1 free acid (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model[4].
| Animal Model: | 6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft[4] | | Dosage: | 0.5 mg | | Administration: | Intratumorally, daily, for 7 days | | Result: | Decreased tumor weight. |
| [storage]
Store at -20°C |
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