| Identification | More | [Name]
Chloramben | [CAS]
133-90-4 | [Synonyms]
3-AMINO-2,5-DICHLOROBENZOIC ACID
AMBEN
AMIBEN
AMIBEN(R)
CHLORAMBEN
TIMTEC-BB SBB003492
VEGIBEN(R)
2,5-Dichloro-3-aminobenzoic acid
2,5-dichloro-3-aminobenzoicacid
3-amino-2,5-dichloro-benzoicaci
Acpm-629
ACP-M-728
Ambiben
Amiben ds
Amiben,Vegiben
amibends
Amibin
Amoben
Benzoic acid, 3-amino-2,5-dichloro-
Chlorambed | [EINECS(EC#)]
205-123-5 | [Molecular Formula]
C7H5Cl2NO2 | [MDL Number]
MFCD00065093 | [Molecular Weight]
206.03 | [MOL File]
133-90-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Chloramben is a colorless, odorless, crystalline solid. | [Melting point ]
200 °C | [Boiling point ]
312 °C | [density ]
1.4062 (rough estimate) | [refractive index ]
1.6100 (estimate) | [storage temp. ]
0-6°C | [solubility ]
Acetonitrile (Slightly), DMSO (Sparingly), Metahnol (Slightly) | [form ]
Powder | [pka]
2.75±0.25(Predicted) | [color ]
Pale Beige | [Water Solubility ]
700 mg/L (25 ºC) | [Merck ]
13,2082 | [BRN ]
2365906 | [Exposure limits]
An experimental carcinogen. | [CAS DataBase Reference]
133-90-4(CAS DataBase Reference) | [NIST Chemistry Reference]
3-Amino-2,5-dichlorobenzoic acid(133-90-4) | [EPA Substance Registry System]
133-90-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xn | [Risk Statements ]
R45:May cause cancer.
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
3
| [RTECS ]
DG1925000
| [HS Code ]
29224999 | [Hazardous Substances Data]
133-90-4(Hazardous Substances Data) | [Toxicity]
Nontoxic to fish (Hartley and Kidd, 1987); acute oral LD50 for rats 5,620 mg/kg
(Hartley and Kidd, 1987), 3,500 mg/kg (RTECS, 1985).
|
| Hazard Information | Back Directory | [General Description]
Purplish white powder or light purple solid. | [Reactivity Profile]
CHLORAMBEN(133-90-4) reacts with sodium hypochlorite solutions . | [Air & Water Reactions]
Insoluble in water. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: This compound emits toxic fumes when heated to decomposition. | [Potential Exposure]
A General Use Pesticide (GUP) that is
no longer produced or sold in the United States. It is used
as an herbicide for grasses, broadleaf weeds, soybeans,
beans, and some vegetables. Workers involved in the manufacture, formulation, or application of this reemergence
herbicide. | [Fire Hazard]
Flash point data for this compound is not available, but CHLORAMBEN is probably combustible. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions,including resuscitation mask) if breathing has stopped and
CPR if heart action has stopped. Transfer promptly to a
medical facility. When this chemical has been swallowed,
get medical attention. Give large quantities of water and
induce vomiting. Do not make an unconscious person
vomit. | [Shipping]
UN2588 Pesticides, solid, toxic, Hazard Class:
6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. | [Incompatibilities]
Rapidly decomposed by light. Strong
acids and acid fumes | [Description]
Chloramben is a colorless, odorless, crystallinesolid. Molecular weight=206.03; Freezing/Meltingpoint=200-201℃; Vapor pressure=6.8 3 1023 mmHg at100℃. Hazard Identification (based on NFPA 704 MRating System): Health 3, Flammability 0, Reactivity 0.Soluble in water; solubility=690 ppm at 25℃. | [Chemical Properties]
Chloramben is a colorless, odorless, crystalline solid. | [Chemical Properties]
Off-white to beige powder | [Waste Disposal]
Chloramben is stable to heat,
oxidation, and hydrolysis in acidic or basic media. The stability is comparable to that of benzoic acid. Wet oxidation
or incineration are recommended disposal methods. | [Uses]
Chloramben may be used as an analytical reference standard for the determination of the analyte in water samples using liquid chromatography with electrochemical detection (LC-EC). | [Uses]
Herbicide or plant growth regulator. | [Uses]
Preemergence or preplant herbicide used in many vegetable and field crops to control
annual broad-leaved weeds and grasses. Also for postemergent control of common ragweed, redroot pigweed, smartweed and velvet-leaf. | [Definition]
ChEBI: Chloramben is a chlorobenzoic acid. | [Agricultural Uses]
Herbicide: A herbicide for grasses, and broadleaf weeds. Mostly
used on soybeans, and also on corn, beans, asparagus, pumpkins,
peanuts, sunflowers, peppers, cotton, sweet potatoes,
squash, melons, hardwood trees, and some conifers. Not approved
for use in EU countries. Not registered for use in
the U.S. There are 51 global suppliers | [Trade name]
ACP-M-728®; AMBEN®; AMBIBEN®;
AMIBEN®[C]; AMIBIN®; AMOBEN®; ORNAMENTAL
WEEDER®[C]; VEGABEN®; VEGIBEN®[C];
WEEDONE® GARDEN WEEDER | [Environmental Fate]
Soil. In soils, chloramben was degraded by microorganisms but no products were
identified (Humburg et al., 1991). The main degradative pathway of chloramben in soil is
decarboxylation and subsequent mineralization to carbon dioxide. The calculated halflives in Ella loamy sand, Kewaunee clay and Poygan silty clay were 120–201, 182–286
and 176–314 days, respectively (Wildung et al., 1968). Persistence in soil is 6–8 weeks
(Hartley and Kidd, 1987).
Groundwater. According to the U.S. EPA (1986) and Ashton and Monaco (1991),
chloramben has a high potential to leach to groundwater, especially in sandy soils during
heavy rains.
Plant. Degrades in plants to N-glucoside, glucose ester, conjugates and insoluble
residues (Ashton and Monaco, 1991).
Photolytic. Plimmer and Hummer (1969) studied the irradiation of chloramben in water
(2–4 mg/L) under a 450-W mercury vapor lamp (λ >2,800 ?) for periods of 2 to 20 hours.
Chloride ion was released and a complex mixture of colored products was observed. It
was postulated that amino free radicals reacted with each other via polymerization and
oxidation processes. The experiment was repeated except the solution contained sodium
bisulfite as an inhibitor under a nitrogen atmosphere. Oxidation did not occur and loss of
the 2-chloro substituent gave 3-amino-5-chlorobenzoic acid (Plimmer and Hummer, 1969).
Chloramben (sodium salt) in aqueous solutions (100 mg/L) was rapidly photodegraded
in outdoor sunlight and under a 360-W mercury arc lamp (Crosby and Leitis, 1969).
In
sunlight, the solution became yellow-brown. Subsequent analysis by gas-liquid chromatography did not resolve any compounds other than chloramben. However, analysis by
TLC indicated at least 12 unidentified products. These products were reportedly formed
via replacement of chlorine by a hydroxy group, reductive dechlorination and abstraction
of hydrogen from the amine group (oxidation). No photodegradation products could be
identified in the solutions irradiated with the mercury arc lamp (Crosby and Leitis, 1969).
Chemical/Physical. Emits toxic fumes of nitrogen oxides and chlorine when heated
to decomposition (Sax and Lewis, 1987).
Forms water-soluble salts with alkalies. | [Metabolism]
Chloramben is generally stable to hydrolytic
degradation; however, it will decompose in sodium
hypochlorite solutions. It is also very sensitive to light
and under oxidative conditions aqueous solutions will
rapidly undergo photolysis. The predominant reaction in
oxidative photolysis is unclear but appears to involve the
formation of amino radicals. Photolysis also occurs under
reductive conditions by dechlorination at the 2 position,
i.e., when appropriate reducing agents are present, e.g.,
sodium bisulfite. | [storage]
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with chloramben you should be trained on its proper handling and storage. Store in a cool, dry place, or a refrigerator, and avoidcontact with strong acids, acid fumes, and light. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHAStandard 1910.1045. | [Toxicity evaluation]
Although limited studies are
available, those that have been conducted, for example,
on cows and dogs, indicate that the majority of ingested
chloramben is quickly excreted through the urine and
feces and does not accumulate in tissues. An interesting
interaction between caffeine and chloramben suggests that
they can form an insoluble complex in the intestinal tract
and thus decrease the amount of chloramben absorbed
into the blood stream. The acute oral LD50 in rat is
>5000 mg/kg. |
|
| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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