| Identification | More | [Name]
CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE | [CAS]
13149-00-3 | [Synonyms]
CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
CIS-CYCLOHEXANE-1,2-DICARBOXYLIC ANHYDRIDE
CIS-HEXAHYDROPHTHALIC ANHYDRIDE
CIS-HHPA
HEXAHYDROPHTHALIC ACID ANHYDRIDE
HEXAHYDROPHTHALIC ANHYDRIDE
HHPA
(3aR,7aS)-Hexahydro-isobenzofuran-1,3-dione
1,3-Isobenzofurandione, hexahydro-, cis-
2-Cyano-3-ethoxy-2-proenoicacidethylester
3-Isobenzofuranedione,hexahydro-,cis-1
cis-cyclohexane-1,2-dicarboxylicacidanhydride
Hexahydro-2-benzofuran-1,3-dione
CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE (HHPA)
1,3-Isobenzofurandione, hexahydro-, (3aR,7aS)-rel-
CIS-1,2-CYCLOHEXANEDECARBOXYLICANHYDRIDE
(3aS)-3aα,4,5,6,7,7aα-Hexahydroisobenzofuran-1,3-dione
(3aα,7aα)-Octahydroisobenzofuran-1,3-dione
3aα,4,5,6,7,7aα-Hexahydroisobenzofuran-1,3-dione
(1R)-Cyclohexane-1β,2α-dicarboxylic anhydride | [EINECS(EC#)]
236-086-3 | [Molecular Formula]
C8H10O3 | [MDL Number]
MFCD00005926 | [Molecular Weight]
154.16 | [MOL File]
13149-00-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to almost white cryst. low melting solid | [Melting point ]
32-34 °C(lit.) | [Boiling point ]
158 °C17 mm Hg(lit.) | [density ]
1.23 | [refractive index ]
1.4750 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Crystalline Low Melting Solid | [color ]
White to almost white | [Sensitive ]
Moisture Sensitive | [BRN ]
83214 | [CAS DataBase Reference]
13149-00-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R41:Risk of serious damage to eyes.
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24:Avoid contact with skin .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
1
| [F ]
10-21 | [HS Code ]
29420000 |
| Hazard Information | Back Directory | [Chemical Properties]
white to almost white cryst. low melting solid | [Uses]
(3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione is a reagent used in the synthesis of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. Also used to prepare P2X7 receptor antagonists. | [Purification Methods]
It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145
1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.] |
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