| Identification | More | [Name]
1-Hydroxy anthraquinone | [CAS]
129-43-1 | [Synonyms]
1-hydroxy-9,10-anthracenedione
1-HYDROXYANTHRAQUINONE
4-HYDROXYANTHRAQUINONE
10-Anthracenedione,1-hydroxy-9
1-hydroxy-10-anthracenedione
1-Hydroxy-9,10-anthraquinone
1-Hydroxyanthra-9,10-quinone
1-Hydroxyanthrachinon
1-hydroxy-anthraquinon
alpha-Hydroxyanthraquinone
Anthraquinone, 1-hydroxy-
I-0syanthrachinon
1-hydroxyanthracene-9,10-dione
NISTC129431
erythroxyanthraquinone | [EINECS(EC#)]
204-946-7 | [Molecular Formula]
C14H8O3 | [MDL Number]
MFCD00058946 | [Molecular Weight]
224.21 | [MOL File]
129-43-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RTECS ]
CB7178000 | [HS Code ]
2914.69.9000 | [Hazardous Substances Data]
129-43-1(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Uses]
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1]. | [Definition]
ChEBI: 1-hydroxyanthraquinone is a monohydroxyanthraquinone. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 55, p. 350, 1990 DOI: 10.1021/jo00288a062 | [in vivo]
1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1]. | Animal Model: | Thirty rats[1]. | | Dosage: | 1% HA in diet. | | Administration: | Diet. | | Result: | Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment.
A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.
Seven animals of the group died spontaneously or were sacrificed upon becoming
moribund between 335 and 462 days.
A total of 21 rats of group 1 survived until the end of experiment (mean value of total
intake of HA/rat was 76.8 g).
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| [References]
[1] H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802. DOI:10.1093/carcin/11.5.799 |
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