| Identification | More | [Name]
Sennoside B | [CAS]
128-57-4 | [Synonyms]
(9S)-9-[(9R)-2-Carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
GLYSENNIDE
PURSENNIDE
SENNOSIDE B
SENNOSIDE B 96.5+%
Sennoside B std.
9,9-Bianthracene-2,2-dicarboxylic acid, 5,5-bis(.beta.-D-glucopyranosyloxy)-9,9,10,10-tetrahydro-4,4-dihydroxy-10,10-dioxo-, (9R,9S)-
(9S)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
SENNIDINE B(RG)
SENNOSIDE B(P)
SENNOSIDE B(SH)
SENNOSIDE B hplc
(9S)-9-[(9R)-2-Carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
SENNOSIDE B WITH HPLC
[9,9'-Bianthracene]-2,2'-dicarboxylicacid,5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-,(9R,9'S)-
(9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-9,9'-bianthracene-2,2'-dicarboxylic acid
(9S,9'R)-5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-9,9'-bianthracene-2,2'-dicarboxylic acid | [EINECS(EC#)]
204-895-0 | [Molecular Formula]
C42H38O20 | [MDL Number]
MFCD00151528 | [Molecular Weight]
862.74 | [MOL File]
128-57-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
209～212℃ | [alpha ]
D20 -100° (c = 0.2 in 70% acetone); D20 -67° (c = 0.4 in 70% dioxane) | [Boiling point ]
698.48°C (rough estimate) | [density ]
1.3066 (rough estimate) | [refractive index ]
1.7630 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Very Slightly, Heated), Methanol (Slightly, Heated) | [form ]
neat | [pka]
3.31±0.40(Predicted) | [color ]
Light Yellow to Dark Yellow | [BRN ]
5723747 | [Stability:]
Hygroscopic | [LogP]
1.880 (est) | [CAS DataBase Reference]
128-57-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3 | [HS Code ]
29329990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to brown powder | [Uses]
Sennoside B is used in the inhibition of platelet driven growth factor (PDGF) used and may inhibit proliferative disease which depend upon the PDGF pathway. Laxative. | [Definition]
ChEBI: A member of the class of sennosides that is (9R,9'S)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D
glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. | [in vivo]
Sennoside B (100 mg/kg; p.o.) shows gastroprotective activities by reducing lesion indices in HCl?EtOH and Indomethacin (HY-14397) induces gastritis in rats[1]. | Animal Model: | 170-200g, Male Sprague-Dawley rats (HCl?EtOH-induced gastritis)[1] | | Dosage: | 100 mg/kg | | Administration: | P.o. | | Result: | Reduced lesion indices to 60.8 ± 18.4 mm, by inhibition rate of 39.9%. |
| [storage]
Store at 2-8°C, protect from light | [Purification Methods]
Sennoside B forms yellow crystals from aqueous acetone or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3402.] |
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