| Identification | More | [Name]
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol | [CAS]
127852-28-2 | [Synonyms]
(R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL
(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL
(R)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL
(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL
R-MBT-PEL
(R)-1-[3,5-BIS(TRIFLUORO-METHYL)-PHENYL]ETHANOL 98%
(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL
Benzenemethanol, a-methyl-3,5-bis(trifluoromethyl)-, (aR)- | [EINECS(EC#)]
603-245-7 | [Molecular Formula]
C10H8F6O | [MDL Number]
MFCD03093010 | [Molecular Weight]
258.16 | [MOL File]
127852-28-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
53-58℃ | [Boiling point ]
175.8±35.0 °C(Predicted) | [density ]
1.376±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly) | [form ]
Powder | [pka]
13.99±0.20(Predicted) | [color ]
White | [optical activity]
[α]/D +27±1°, c = 1 in acetonitrile | [λmax]
272nm(MeOH)(lit.) | [InChIKey]
MMSCIQKQJVBPIR-RXMQYKEDSA-N | [CAS DataBase Reference]
127852-28-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
29062990 |
| Questions And Answer | Back Directory | [Uses]
(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions. | [Preparation]
At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity. |
| Hazard Information | Back Directory | [Chemical Properties]
White fine crystalline powder | [General Description]
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor. |
|
|