| Identification | More | [Name]
Cyclobutanone | [CAS]
1191-95-3 | [Synonyms]
CBON
CYCLOBUTANONE
Cyclobutanone, 98+%
Cyclobutanone 98%
Cyclobutanone, 98%, stab. with ca 0.01% BHT | [EINECS(EC#)]
214-745-6 | [Molecular Formula]
C4H6O | [MDL Number]
MFCD00001332 | [Molecular Weight]
70.09 | [MOL File]
1191-95-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colourless to slightly yellow liquid | [Melting point ]
-50.9 °C
| [Boiling point ]
99 °C (lit.) | [density ]
0.938 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.421(lit.)
| [Fp ]
50 °F
| [storage temp. ]
0-6°C | [form ]
Liquid | [color ]
Clear colorless to slightly yellow | [Specific Gravity]
0.938 | [Water Solubility ]
INSOLUBLE | [BRN ]
1560289 | [InChIKey]
SHQSVMDWKBRBGB-UHFFFAOYSA-N | [CAS DataBase Reference]
1191-95-3(CAS DataBase Reference) | [EPA Substance Registry System]
1191-95-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,F+ | [Risk Statements ]
R10:Flammable.
R11:Highly Flammable. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S9:Keep container in a well-ventilated place .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains .
S16:Keep away from sources of ignition-No smoking .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 1224 3/PG 3
| [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29142900 |
| Questions And Answer | Back Directory | [Description]
Cyclobutanone is an organic compound with a four-membered cyclic ketone. It is used in preparation of cyclobutane derivatives, as a starting material for aminocyclobutanecarboxylic acid through sulfonyloxiranes, to prepare dihydro-furan-2-one in presence of polystyrene-bound phenylselenic acid as catalyst. It is also involved in the photochemical synthesis of nucleoside analogues such as bicyclic nucleosides and isonucleosides. Furthermore, it is used to synthesis fatty acid, 2-oxo-cyclobutane undecanoic acid, which is used in the development of an enzyme-linked immunosorbent assy for the detection of irradiated foods. | [References]
[1] https://en.wikipedia.org/wiki/Cyclobutanone
[2] https://www.alfa.com/de/catalog/A13068/
[3] https://www.scbt.com/scbt/de/product/2-oxo-cyclobutane-undecanoic-acid-169263-77-8/;jsessionid=Ay2KMCxORq9y-EC6YoYnGGtCnymUGxQi5Lpd-YuCZoW22Re8Xf4w!-2072765631 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colourless to slightly yellow liquid | [Uses]
Cyclobutanone is used in preparation of cyclobutane derivatives. It is used as a starting material for aminocyclobutanecarboxylic acid through sulfonyloxiranes. It is also used to prepare dihydro-furan-2-one in presence of polystyrene-bound phenylselenic acid as catalyst. Further, it is involved in the photochemical synthesis of nucleoside analogues such as bicyclic nucleosides and isonucleosides. | [Preparation]
The Russian chemist Nikolai Kischner first prepared cyclobutanone in 1905. He synthesized cyclobutanone in a low yield from cyclobutanecarboxylic acid in several reaction steps.
Another synthesis of cyclobutanone involves lithium-catalyzed rearrangement of oxaspiropentane, which is formed by epoxidation of the easily accessible methylenecyclopropane. | [Purification Methods]
Treat cyclobutanone with dilute aqueous KMnO4, dry it with molecular sieves and fractionally distil it. Purify it via the semicarbazone, then regenerate the ketone, dry it (CaSO4), and distil it in a stainless steel spinning-band (or Vigreux, p 11) column. Alternatively, purify it by preparative gas chromatography using a Carbowax 20-M column at 80o. (This treatment also removes acetone). The oxime has m 84-85o (from pet ether) and the semicarbazone has m 212-212-5o (220-221o from MeOH or H2O, Buchanan et al. J Am Chem Soc 64 2701 1942). [Salaun Org Synth 57 36 1977, Fitzer & Quabeck Synthesis 299 1987, Beilstein 7 IV 3.] |
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