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ChemicalBook--->CAS DataBase List--->1147-56-4

1147-56-4

1147-56-4 Structure

1147-56-4 Structure
IdentificationMore
[Name]

1-(2-THIAZOLYLAZO)-2-NAPHTHOL
[CAS]

1147-56-4
[Synonyms]

1-(2-THIAZOLYLAZO)-2-NAPHTHOL
2-(2-HYDROXY-1-NAPHTHYLAZO)THIAZOLE
TAN
1-(2’-Thiazolylazo)-β-naphtho
1-(2-thiazolylazo)-2-naphthaleno
1-(2-thiazolylazo)-2-Naphthalenol
1-(thiazol-2-ylazo)-2-naphthol
1-(2'-Thiazolylazo)-β-naphthol
TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals]
2-(2-Hydroxy-1-naphthylazo)thiazole, TAN
1-(Thiazole-2-ylazo)-2-naphthol
1-(Thiazole-2-ylazo)naphthalene-2-ol
1-[(Thiazole-2-yl)azo]-2-naphthol
Nitrilotantalum(III)
[EINECS(EC#)]

214-555-3
[Molecular Formula]

C13H9N3OS
[MDL Number]

MFCD00021611
[Molecular Weight]

255.3
[MOL File]

1147-56-4.mol
Chemical PropertiesBack Directory
[Melting point ]

138-139 °C
[Boiling point ]

464.8±47.0 °C(Predicted)
[density ]

1.40
[storage temp. ]

2-8°C
[solubility ]

methanol: 10 mg/mL, clear
[form ]

solid
[pka]

8.71±0.50(Predicted)
[color ]

Red or orange
[BRN ]

223783
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
[CAS DataBase Reference]

1147-56-4(CAS DataBase Reference)
[EPA Substance Registry System]

2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4)
Safety DataBack Directory
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
[WGK Germany ]

3
[TSCA ]

Yes
[HS Code ]

2927.00.5000
Hazard InformationBack Directory
[Description]

ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.
[Uses]

1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
[storage]

Store at -20°C
[References]

1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659
Spectrum DetailBack Directory
[Spectrum Detail]

1-(2-THIAZOLYLAZO)-2-NAPHTHOL(1147-56-4)MS
1-(2-THIAZOLYLAZO)-2-NAPHTHOL(1147-56-4)1HNMR
1-(2-THIAZOLYLAZO)-2-NAPHTHOL(1147-56-4)13CNMR
1-(2-THIAZOLYLAZO)-2-NAPHTHOL(1147-56-4)IR1
1-(2-THIAZOLYLAZO)-2-NAPHTHOL(1147-56-4)IR2
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

1-(2-Thiazolylazo)-2-naphthol, 98%(1147-56-4)
[Sigma Aldrich]

1147-56-4(sigmaaldrich)
[TCI AMERICA]

TAN  [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals],>99.0%(T)(1147-56-4)
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