| Identification | More | [Name]
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | [CAS]
111974-74-4 | [Synonyms]
11-(1-piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
11-Piperazinodibenzo[b,f][1,4]thiazepine dihydrochloride
11-PIPERAZINYL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCl (DBTP)
11-Piperazynil-Dibenzo[b,f][1,4]Thiazepine DIHYDROCHLORIDE
DibenzoB,F1,4Thiazepine-11-Piperazine2Hcl
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine,2HCl
N-Des[2-(2-hydroxyethoxy)ethyl]Quetiapinedihydrochloride
N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazine2HCl
N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazinedihydrochloride
11-Piperazynil-dibenzo (b,f)(1,4)thiazepine-11-piperazine 2HCl
1-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPINEDIHYDROCHLORIDE
11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP, | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C17H19Cl2N3S | [MDL Number]
MFCD08703302 | [Molecular Weight]
368.324 | [MOL File]
111974-74-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale-Yellow Solid | [Melting point ]
180-184°C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO, Methanol, Distilled Water | [form ]
solid | [color ]
Off-white | [Usage]
A metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months. | [InChI]
InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H | [InChIKey]
MJPARFLICDXWJT-UHFFFAOYSA-N | [SMILES]
C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl | [CAS DataBase Reference]
111974-74-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4 | [Chemical Properties]
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
| [Uses]
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
| [References]
1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213
2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102
3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209
4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709 |
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