| Identification | More | [Name]
BIOTINAMIDOCAPROYL HYDRAZIDE | [CAS]
109276-34-8 | [Synonyms]
6-[(+)-BIOTINYL]AMINOCAPROIC ACID HYDRAZIDE
BIOTINAMIDOCAPROYL HYDRAZIDE
BIOTINAMIDOCAPROYL HYDRAZINE
BIOTIN-EPSILON-AMINOCAPROYL HYDRAZIDE
BIOTIN LC HYDRAZIDE
BIOTIN LC HYDRAZINE
BIOTIN-X-HYDRAZIDE
(+)-BIOTINAMIDOHEXANOIC ACID HYDRAZIDE
(+)-biotin-ε-aminocaproyl hydrazide
6-(Biotinylamino)hexanoylhydrazine
Biotin-6-aminocaproyl hydrazide
LC-(+)-Biotin hydrazide
N-biotinyl-6-aminocaproic hydrazide
(+)-Biotin-ε-aminocaproyl hydrazide, (+)-Biotin-X-hydrazide, (+)-Biotinamidocaproyl hydrazide, BACH, N-(+)-Biotinyl-6-aminohexanoic hydrazide | [Molecular Formula]
C16H29N5O3S | [MDL Number]
MFCD00077659 | [Molecular Weight]
371.5 | [MOL File]
109276-34-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
195-196°C | [Boiling point ]
777.0±55.0 °C(Predicted) | [density ]
1.188±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: 25 mg/mL
| [form ]
powder
| [pka]
13.26±0.35(Predicted) | [color ]
White to Almost white | [InChIKey]
IJJWOSAXNHWBPR-HUBLWGQQSA-N | [CAS DataBase Reference]
109276-34-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
-
| [F ]
10-21 | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Description]
This is a hydrazide-activated biotinylation reagent used to label glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds. The extended spacer arm helps to minimize steric hindrance. | [Chemical Properties]
mp 195°C | [Uses]
Biotinylation reagent with aminocaproic spacer for aldehyde groups (e.g., periodate-oxidized sugars) and carboxylic acids. Typically used for coupling to glycoproteins through the carbohydrate by hydrazone bond formation. | [Purification Methods]
Suspend the hydrazide in ice-water (100mg/mL), stand overnight at 4o, filter and dry the solid in a vacuum. Recrystallise it from isoPrOH. RF is 0.26 on SiO2 plate using CHCl3/MeOH (7:3) as eluent. [O'Shannessy et al. Anal Biochem 163 204 1987.] |
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