| Identification | Back Directory | [Name]
GSK-2126458 | [CAS]
1086062-66-9 | [Synonyms]
CS-55
GSK212
GSK458
HYR-582
GSK2126458
OMipalisib
GSK-2126458
GSK2126458, >=98%
Omipalisib GSK458
GSK2126458 (GSK458)
GSK-2126458 USP/EP/BP
GSK2126458(Omipalisib)
Omipalisib GSK2126458
GSK2126458; GSK-2126458
GSK2126458 (HYR-582)
Omipalisib (GSK2126458, GSK458)
GSK2126458 (GSK458);GSK458;GSK-212; GSK-2126458
Omipalisib, 98%, a highly selective and potent inhibitor of PI3K
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide
Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
GSK 2126458
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide GSK2126458(GSK458) | [EINECS(EC#)]
629-873-1 | [Molecular Formula]
C25H17F2N5O3S | [MDL Number]
MFCD16038929 | [MOL File]
1086062-66-9.mol | [Molecular Weight]
505.5 |
| Chemical Properties | Back Directory | [Melting point ]
187-189℃ | [Boiling point ]
715.6±70.0 °C(Predicted) | [density ]
1.45 | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated) | [form ]
Solid | [pka]
6.23±0.40(Predicted) | [color ]
White to Pale Yellow |
| Hazard Information | Back Directory | [Description]
GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively).1 It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α.1 GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models.1 GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 (Item No. 18092) to suppress the growth of SNU-1040 colorectal cancer cells.2 | [Uses]
A highly potent inhibitor of PI3K and the mammalian target of Rapamycin. | [Definition]
ChEBI: Omipalisib is a member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors. It has a role as an autophagy inducer, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor, a mTOR inhibitor, an antineoplastic agent, a radiosensitizing agent and an anticoronaviral agent. It is a member of quinolines, a difluorobenzene, a sulfonamide, an aromatic ether, a member of pyridines and a member of pyridazines. | [target]
p110α | [storage]
Store at -20°C |
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