| Identification | Back Directory | [Name]
3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo- | [CAS]
108466-89-3 | [Synonyms]
Boc-AEEA-OH
2-diMethyl-4-oxo-
BocNH-PEG2-CH2COOH
Boc-N-amido-PEG2-CH2CO2H
t-Boc-N-amido-PEG2-CH2CO2H
T-BOC-NH-AMIDO-PEG2-CH2CO2H
t-boc-N-amido-PEG2-acetic acid
11-Trioxa-5-azatridecan-13-oic acid
2-[2-[2-(Boc-amino)ethoxy]ethoxy]acetic Acid
8-tert-butyloxycarbonylaMino-3,6-dioxaoctanoic acid
2,2-DiMethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid
3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-
3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo-
2-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethoxy]acetic acid
3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo- USP/EP/BP
2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylaMino]ethoxy]ethoxy]acetic acid | [Molecular Formula]
C11H21NO6 | [MDL Number]
MFCD17019374 | [MOL File]
108466-89-3.mol | [Molecular Weight]
263.29 |
| Hazard Information | Back Directory | [Description]
t-Boc-N-amido-PEG2-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
t-Boc-N-amido-PEG2-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG2-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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