| Identification | More | [Name]
1,2-EPOXYBUTANE | [CAS]
106-88-7 | [Synonyms]
1,2-BUTYLENE OXIDE
1,2-EPOXYBUTANE
1-BUTENE OXIDE
ALPHA-BUTYLENE OXIDE
ETHYLETHYLENE OXIDE
ETHYLOXIRANE
ETHYLOXITANE
(R,S)-2-Ethyl-oxirane
1,2-Butene oxide
1,2-buteneoxide
1,2-butyleneepoxide
1,2-butyleneoxide,stabilized
1,2-epoxy
1,2-epoxy-butan
1,2-epoxybutane(1,2-butyleneoxide)
1,2-epoxybutylene
1,2-Monoepoxybutane
1-Butylene oxide
1-butyleneoxide
2-Ethyloxirane | [EINECS(EC#)]
203-438-2 | [Molecular Formula]
C4H8O | [MDL Number]
MFCD00005153 | [Molecular Weight]
72.11 | [MOL File]
106-88-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Butylene oxide is a watery-white liquid with
and ethereal odor. | [Melting point ]
-129.28°C | [Boiling point ]
63 °C(lit.)
| [density ]
0.829 g/mL at 20 °C(lit.) | [vapor density ]
2.2 (vs air)
| [vapor pressure ]
140 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.384
| [Fp ]
10 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
86.8g/l | [form ]
Colorless liquid with
pungent odor | [color ]
Colorless to Almost colorless | [PH]
7 (50g/l, H2O, 20℃) | [Stability:]
Stable, but prone to polymerization-stabilizer may be added to neat liquid. Highly flammable. Incompatible with strong oxidizing agents, acids, bases, anhydrous metal halides, amino, hydroxyl and carboxyl-containing compounds. Inorganic acids and charcoal may lead to polymerization. Heat, light and moisture sensitive. | [explosive limit]
1.7-19%(V) | [Water Solubility ]
86.8g/L at 25℃ | [BRN ]
102411 | [InChIKey]
RBACIKXCRWGCBB-UHFFFAOYSA-N | [LogP]
0.68 at 25℃ | [Uses]
Intermediate for various polymers, stabilizer for
chlorinated solvents.
| [CAS DataBase Reference]
106-88-7(CAS DataBase Reference) | [IARC]
2B (Vol. 47, 71) 1999 | [EPA Substance Registry System]
1,2-Butylene oxide (106-88-7) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xn | [Risk Statements ]
R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S29:Do not empty into drains .
S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3022 3/PG 2
| [WGK Germany ]
2
| [RTECS ]
EK3675000
| [Autoignition Temperature]
698 °F | [TSCA ]
Yes | [HazardClass ]
3.1 | [PackingGroup ]
II | [HS Code ]
29109000 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic data.
Moderately toxic by ingestion and skin
contact. Mtldly toxic by inhalation.
Experimental reproductive effects. Mutation
data reported. Dangerous fire hazard when
exposed to heat, flame, or powerful
oxidizers. To fight fire, use dry chemical,
water spray, mist or fog, alcohol foam.
When heated to decomposition it emits
acrid smoke and fumes. | [Hazardous Substances Data]
106-88-7(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 500 mg/kg LD50 dermal Rabbit 1743 mg/kg |
| Hazard Information | Back Directory | [General Description]
A clear colorless volatile liquid with an ethereal odor. Flash point near 0°F. Density about 6.9 lb/gal. Soluble in water. Boiling point near 140°F. Flammable over a wide range of vapor-air concentrations. May polymerize with the evolution of heat and possible rupture of container if contaminated. Vapors irritate eyes, skin and respiratory system. Prolonged contact with skin may cause in delayed burns. Vapors are heavier than air. Used as an intermediate to make various polymers. Chemicals that polymerize are often stabilized by refrigeration. | [Reactivity Profile]
Epoxides, such as 1,2-BUTYLENE OXIDE(106-88-7), are highly reactive. They polymerize in the presence of catalysts or when heated. Contact with anhydrous metal halides; amino, hydroxyl and carboxyl functions; inorganic acids and charcoal may cause polymerization. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts. | [Air & Water Reactions]
Highly flammable. Soluble in water and may decompose upon contact with water. | [Hazard]
Toxic concentration of vapors occurs at
room temperature. Highly flammable, dangerous
fire risk. Possible carcinogen.
| [Health Hazard]
Inhalation: intolerable odor and irritation; respiratory injury may occur at higher levels. Ingestion causes irritation of mouth and stomach. Contact with either liquid or vapor may cause burns of eyes. Liquid produces frostbite-type of skin burn if free to evaporate; if confined to skin, burn may cause skin sensitization; not readily absorbed in toxic amounts. | [Potential Exposure]
It is used as a stabilizer in chlorinated
solvents, and to make other chemicals, such as gasoline
additives. | [Fire Hazard]
Behavior in Fire: Containers may explode in fire. Use water to cool container from safe distance. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Medical observation is recommended for 24 to 48 hoursafter breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy | [Shipping]
UN3022 1,2-Butylene oxide, stabilized, Hazard
Class: 3; Labels: 3—Flammable liquid | [Incompatibilities]
May form explosive mixture with air.
Unless inhibited, can form unstable and explosive peroxides. Before entering confined space where this chemical
may be present, check to make sure that an explosive concentration does not exist. Polymerization will occur in the
presence of acids, strong bases and chlorides of tin, iron and
aluminum. Storage tanks and other equipment should be
absolutely dry and free from air, ammonia, acetylene,
hydrogen sulfide, rust and other contaminants. Incompatible
with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline
materials, strong bases, strong acids, oxoacids, epoxides.
Attacks some plastics. May accumulate static electric
charges that can result in ignition of its vapors. A regulated,
marked area should be established where this chemical is
handled, used, or stored in compliance with OSHA Standard
1910.1045. | [Description]
Butylene oxide is a watery white liquid withan etherial odor. Molecular weight = 72.1 (1,2- and 2,3-isomers);Specific gravity (H2O:1) = 0.83; Boilingpoint = 63.3℃; Freezing/Melting point = - 130℃; Vaporpressure = 142 mmHg at 20℃; 176 mmHg at 25℃;Relative vapor density (air = 1) = 2.2; Relative density ofthe vapor/air mixture at 20C (air = 1) = 1.3; Flashpoint = - 22℃; Autoignition temperature = 439℃.Explosive limits in air: LEL: 1.7%; UEL: 19%. HazardIdentification (based on NFPA-704 M Rating System):Health 2, Flammability 3, Reactivity 2. Soluble in water;solubility = 9.5% at 25℃. | [Chemical Properties]
1,2-Butylene oxide is a colorless mobile liquid with an unpleasant smell. This low boiling liquid has but limited water solubility, yet is miscible with most common organic solvents. It undergoes the usual reactions of epoxides with compounds having labile hydrogen atoms. Some of these are acids, amines, ammonia, alcohols, phenols, polyols, thiols, etc. Butylene oxide can be polymerized or copolymerized with other alkylene oxides to yield polyethers. The resulting polymers are less water soluble than the polymers made from ethylene and propylene oxide, of equivalent chain length.
| [Chemical Properties]
Butylene oxide is a watery-white liquid with
and ethereal odor. | [Definition]
ChEBI: 1,2-Epoxybutane is an epoxide. | [Flammability and Explosibility]
Highlyflammable | [Carcinogenicity]
Exposure to 1000 ppm before and during
gestation did not cause any teratogenic effects
in rats; fetal growth and viability were not
affected despite depressed maternal body
weight gain.6 Rabbits exposed at 250 or
1000ppm 7 hours/day during gestational days
0 to 24 had maternal deaths at both exposure
concentrations. No teratogenic effects were
observed, although the pregnancy rate was
reduced in the high-dose group. 1,2-Epoxybutane
is a direct-acting alkylating agent, and it is
genotoxic in a wide range of assays.
Instilled in the eyes of rabbits, 1,2-
epoxybutane caused corneal injury.
A threshold limit value (TLV) has not been
established for 1,2-epoxybutane, although US
manufacturers have recommended a voluntary
time-weighted average-threshold limit value of
40ppm. | [storage]
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with this chemical acid you should betrained on its proper handling and storage. Protect againstphysical damage. Store only if inhibited. Outside ordetached storage is preferred. Store in tightly closed containers in a cool, well-ventilated area away from incompatible materials listed above. Metal containers involving thetransfer of this chemical should be grounded and bonded.Drums must be equipped with self-closing valves, pressurevacuum bungs, and flame arresters. Use only nonsparkingtools and equipment, especially when opening and closingcontainers of this chemical. Sources of ignition, such assmoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could createa potential fire or explosion hazard. A regulated, markedarea should be established where this chemical is handled,used, or stored in compliance with OSHA Standard1910.1045. | [Purification Methods]
Dry it with CaSO4, and fractionally distil it through a long (126cm) glass helices-packed column. The first fraction contains a water azeotrope. [Beilstein 17 II 17.] |
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