| Identification | More | [Name]
4-Chlorotoluene | [CAS]
106-43-4 | [Synonyms]
1-CHLORO-4-METHYLBENZENE
4-CHLORO-1-METHYLBENZENE
4-CHLOROTOLUENE
4-Chlorotoluene p-Chlorotoluene
AKOS BBS-00004363
P-CHLOROTOLUENE
PCT
1-chloro-4-methyl-benzen
1-Methyl-4-chlorobenzene
4-Chlortoluol
4-Methylphenylchloride
4-Tolylchloride
Benzene,1-chloro-4-methyl-
chloro-4toluene
chlorotoluenes
para-Chlorotoluene
p-Chloromethylbenzene
p-chloro-toluen
p-Chlortoluol
p-Methylchlorobenzene | [EINECS(EC#)]
203-397-0 | [Molecular Formula]
C7H7Cl | [MDL Number]
MFCD00000631 | [Molecular Weight]
126.58 | [MOL File]
106-43-4.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
6-8 °C(lit.)
| [Boiling point ]
162 °C(lit.)
| [density ]
1.07 g/mL at 25 °C(lit.)
| [vapor density ]
4.38 (vs air)
| [vapor pressure ]
10 mm Hg ( 45 °C)
| [refractive index ]
n20/D 1.52(lit.)
| [Fp ]
121 °F
| [storage temp. ]
0-6°C | [solubility ]
0.040g/l | [form ]
Liquid | [color ]
Clear | [PH]
7.4 (H2O)(saturated aqueous solution) | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [explosive limit]
0.7-12.2%(V) | [Water Solubility ]
<0.1 g/100 mL at 20 ºC | [Merck ]
14,2171 | [BRN ]
1903635 | [Dielectric constant]
6.0800000000000001 | [LogP]
3.33 at 20℃ | [CAS DataBase Reference]
106-43-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1-chloro-4-methyl-(106-43-4) | [EPA Substance Registry System]
106-43-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N,T,F | [Risk Statements ]
R20:Harmful by inhalation.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
R10:Flammable. | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [RIDADR ]
UN 2238 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
XS9010000
| [Hazard Note ]
Harmful | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29036990 | [HS Code ]
29337900 | [Safety Profile]
Moderately toxic by
ingestion. Mdly toxic by inhalation.
Flammable when exposed to heat or flame.
When heated to decomposition it emits
toxic fumes of Cl-. See also TOLYL
CHLORIDE and CHLORINATED
HYDROCARBONS, AROMATIC. | [Hazardous Substances Data]
106-43-4(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Hazard]
Avoid inhalation; strong irritant. | [Chemical Properties]
colourless liquid | [Uses]
4-Chlorotoluene is used in a variety of organic synthesis, such as acting as coupling precursors for palladium-catalyzed acylation of acetanilides. | [Uses]
Solvent; dyestuff intermediate; in organic syntheses. | [Application]
4-chlorotoluene is used as a solvent and intermediate for dyes and other organic chemicals. It is used mainly to produce p-chlorobenzotrichloride, from whichis obtained p-chlorobenzotrifluoride, an important precursor of herbicides (e.g., trifluralin:α,α,α,-trifluoro-2,6-dinitro-N,Ndipropyl-p-toluidine). Other side-chain-chlorinated products or their derivatives are 4- chlorobenzyl chloride (for pharmaceuticals, rice herbicides, and pyrethrin insecticides), 4- chlorobenzaldehyde (for dyes and pharmaceuticals), 4-chlorobenzoyl chloride (for pharmaceuticals and peroxides), and 4-chlorobenzoic acid (for dyes). 4-Chlorotoluene is also a starting material in the synthesis of 2,4- and 3,4-dichlorotoluene and of 4-chlorobenzonitrile. [ChemicalBook] | [Definition]
ChEBI: 4-Chlorotoluene is a member of monochlorobenzenes. | [Preparation]
4-Chlorotoluene is obtained from p-toluidine by diazotization and substitution. Add p-toluidine and hydrochloric acid to the reaction pot and stir and heat until dissolved at 60℃, then cool to below 15℃ and add sodium nitrite solution dropwise. After reaching the end point, continue to stir for 0.5h. Add cuprous chloride hydrochloric acid solution and stir at room temperature for 3h. Then raise the temperature to 60℃ and keep for 0.5h, cool to room temperature and leave to stratify, discard the acid water layer, wash with water to neutral, filter and get p-chlorotoluene. | [General Description]
The reaction of 4-chlorotouleneand phenylboronic acid with Pd(OAc)2/L?2HX as the catalyst is the model reaction for determining the efficiencies of bisimidazolylidene (L) ligand precursors. | [Flammability and Explosibility]
Flammable | [Purification Methods]
Dry it with BaO, fractionally distil it, then fractionally crystallise it by partial freezing. [Beilstein 5 IV 806.] |
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