| Identification | More | [Name]
4-Bromophenol | [CAS]
106-41-2 | [Synonyms]
4-BROMOHYDROXYBENZENE
4-BROMOPHENOL
4-Bromophenol p-Bromophenol
AKOS BBS-00004402
BROMOPHENOL-4
P-BROMOPHENOL
1,4-bromophenol
4-bromo-pheno
p-bromohydroxybenzene
p-bromophenicacid
p-bromo-pheno
Phenol, 4-bromo-
Phenol, p-bromo-
Phenol,4-bromo-
4-Bromophbenol
4-Bromophenoles
p-Bromophenoles
p-Bromophenol 4-Bromophenol
4-BROMOPHENOL, 1000MG, NEAT
Para Bromo Phenol | [EINECS(EC#)]
203-394-4 | [Molecular Formula]
C6H5BrO | [MDL Number]
MFCD00002313 | [Molecular Weight]
173.01 | [MOL File]
106-41-2.mol |
| Chemical Properties | Back Directory | [Appearance]
pinkish-brown crystalline solid | [Melting point ]
61-64 °C (lit.) | [Boiling point ]
235-236 °C (lit.) | [density ]
1.84 | [refractive index ]
1.5085 (estimate) | [Fp ]
235-238°C | [storage temp. ]
room temp | [solubility ]
14g/l | [form ]
Crystalline Solid | [pka]
9.37(at 25℃) | [color ]
Pinkish-brown | [Water Solubility ]
It is insoluble in water. It is soluble in 5%ethanol. | [Usage]
Intermediates of Liquid Crystals | [λmax]
282nm(EtOH)(lit.) | [Merck ]
14,1428 | [BRN ]
1680024 | [CAS DataBase Reference]
106-41-2(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Bromophenol(106-41-2) | [Storage Precautions]
Store under inert gas;Light sensitive | [EPA Substance Registry System]
Phenol, 4-bromo- (106-41-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
2
| [RTECS ]
SJ7960000
| [F ]
8-10-23 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29081900 | [Hazardous Substances Data]
106-41-2(Hazardous Substances Data) | [Toxicity]
mouse,LD50,intraperitoneal,411mg/kg (411mg/kg),Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(12), Pg. 19, 1979. |
| Hazard Information | Back Directory | [Chemical Properties]
4-Bromophenol is a pinkish-brown crystalline solid. four-sided biconical crystal precipitated from ether or chloroform. The melting point is 66.4 ℃, and a small amount of water can reduce the melting point a lot. Soluble in water, chloroform, easily soluble in ethanol, ether and glacial acetic acid, soluble in 7 parts of water. | [Uses]
4-Bromophenol is used as an intermediate in medicine grade. It is also used as a phenol that is used in Stille reactions. It is used in the intermediate of organic synthesis, flame retardant and pharmaceutical industry. | [Application]
4-Bromophenol is a phenolic derivative that It can used as a reagent in Stille reactions or Intermediates of Liquid Crystals. | [Definition]
ChEBI: 4-bromophenol is a bromophenol containing only hydroxy and bromo substituents that are para to one another. It has a role as a mouse metabolite, a persistent organic pollutant, a human xenobiotic metabolite, a rat metabolite, a human urinary metabolite and a marine metabolite. | [Preparation]
4-Bromophenol is synthesized by bromination of phenol. The bromine and carbon disulfide solution was added to the phenolic carbon disulfide solution, and the addition was started below 5°C, and the addition was completed under stirring for 2 hours. Phenol and bromine are approximately equimolar ingredients. Distill the reactant to remove carbon disulfide, and then conduct fractional distillation under reduced pressure to collect fractions at 145-150°C (3.32-3.99kPa) to obtain the product. Yield 80-84%. | [Synthesis Reference(s)]
Tetrahedron, 45, p. 7869, 1989 DOI: 10.1016/S0040-4020(01)85800-2
The Journal of Organic Chemistry, 23, p. 280, 1958 DOI: 10.1021/jo01096a033 | [Purification Methods]
Crystallise the phenol from CHCl3, CCl4, pet ether (b 40-60o), or water and dry it at 70o under vacuum for 2hours. [Beilstein 6 IV 1043.] |
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