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ChemicalBook CAS DataBase List TRIETHYL 2-PHOSPHONOPENTANOATE
35051-49-1

TRIETHYL 2-PHOSPHONOPENTANOATE synthesis

7synthesis methods
-

Yield:35051-49-1 93.26%

Reaction Conditions:

Stage #1: diethoxyphosphoryl-acetic acid ethyl esterwith potassium tert-butylate in dimethyl sulfoxide at 0; for 0.5 h;
Stage #2: 1-iodo-propane in dimethyl sulfoxide at 60; for 1.5 h;

References:

Kong, Qidi;Pan, Wei;Xu, Heng;Xue, Yaru;Guo, Bin;Meng, Xin;Luo, Cheng;Wang, Ting;Zhang, Shuhua;Yang, Yushe [Journal of Medicinal Chemistry,2021,vol. 64,# 12,p. 8644 - 8665] Location in patent:supporting information

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