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154002-73-0

(+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID synthesis

1synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
832 suppliers
$13.50/25G

(+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID

154002-73-0
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: NaHCO3 / methanol / 16 h / 60 °C
2: NaIO4 / tetrahydrofuran; H2O / 2 h / 20 °C
3: 27 g / NaBH4 / methanol / 0.5 h / 0 °C
4: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
5: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
6: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7

References:

Alegret, Carlos;Santacana, Ferran;Riera, Antoni [Journal of Organic Chemistry,2007,vol. 72,# 20,p. 7688 - 7692]

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