Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) synthesis
1synthesis methods
- Product Name:Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane)
- CAS Number:25382-33-6
- Molecular formula:C15H18N2
- Molecular Weight:226.32
Yield:-
Reaction Conditions:
Stage #1: picolinewith lithium diisopropyl amide in tetrahydrofuran;n-heptane;ethylbenzene at -78; for 1 h;
Stage #2: 1,3-dibromo-propane in tetrahydrofuran;n-heptane;ethylbenzene at -78 - 20; for 24 h;
References:
Atoini, Youssef;Prasetyanto, Eko Adi;Chen, Pengkun;Silvestrini, Simone;Harrowfield, Jack;De Cola, Luisa [Chemistry - A European Journal,2018,vol. 24,# 46,p. 12054 - 12060] Location in patent:supporting information