Thieno[3,4-c]furan-1,3(4H,6H)-dione synthesis

6synthesis methods

Product Name:Thieno[3,4-c]furan-1,3(4H,6H)-dione
CAS Number:75532-25-1
Molecular formula:C6H4O3S
Molecular Weight:156.16

3,4-Thiophenedicarboxylic acid, 2,5-dihydro-

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75532-25-1
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Yield:75532-25-1 84%

Reaction Conditions:

with acetyl chloride for 1 h;Reflux;

Steps:

5 2,2,4,4-Tetrahydrothiophene-3,4-dicarboxylic anhydride, Compound (2)
Experimental methods for step 5: A solution of compound (1) (6.05 g, 34.7 mmol) in acetyl chloride (30 mL, 5 vol) is refluxed for 1 hour. The reaction mixture is concentrated under reduced pressure and dissolved in a small amount of dichloromethane and triturated with heptanes. The resulting solid is filtered and dried overnight under high vacuum to afford product (2) (4.47 g, 84%) as an off-white solid.

References:

VERRICA PHARMACEUTICALS, INC.;DAVIDSON, Matthew;SCHOW, Steven R. WO2016/100732, 2016, A2 Location in patent:Paragraph 0109

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2689-68-1 Synthesis