TETRAHYDRO-FURAN-3-CARBONYL CHLORIDE synthesis
- Product Name:TETRAHYDRO-FURAN-3-CARBONYL CHLORIDE
- CAS Number:69595-02-4
- Molecular formula:C5H7ClO2
- Molecular Weight:134.56
89364-31-8
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69595-02-4
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$60.00/100mg
Yield: 99%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 0.5 h;
Steps:
82.a
To a solution of tetrahydro-3 -furancarboxylic acid (500 mg, 4.31 mmol) in Dichloromethane (DCM) (10 ml) was added oxalyl chloride (1.131 ml, 12.92 mmol), followed by 2 drops of DMF. The mixture was stirred at room temperature for 30 min, and then excess oxalyl chloride and dichloromethane were removed in vacuo to provide crude tetrahydro-3-furancarbonyl chloride (575 mg, 99%).
References:
GLAXOSMITHKLINE LLC;LIN, Hong;LUENGO, Juan, I.;RIVERO, Ralph, A.;SCHULZ, Mark, James;XIE, Ren;ZENG, Jin WO2010/135504, 2010, A1 Location in patent:Page/Page column 74-75
488-93-7
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69595-02-4
36 suppliers
$60.00/100mg