tetrabroMobisphenol-A-polycarbonate synthesis
- Product Name:tetrabroMobisphenol-A-polycarbonate
- CAS Number:28643-16-5
- Molecular formula:C6H6ClN3O2
- Molecular Weight:187.58
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Yield: 940 mg
Reaction Conditions:
with trichlorophosphate in N,N-dimethyl-formamide at 100; for 16 h;
Steps:
11.2
Step 2: A mixture of 2-amino-3-(methoxycarbonyl)pyrazine1-oxide (5.50 g, 32.5 mmol) and POCl3 (15.2 mL,163 mmol) in DMF (30 mL) was heated at100°C for16 h. After cooling to room temperature, the mixture was diluted with H2O (300 mL) and adjust to pH = 7 with solid NaHCO3. The resulting mixture was extracted with ethyl acetate (2 x 200 mL). The combined organic layers were washed with brine (100 mL), dried and concentrated to dryness. The residue was purified by column chromatography (silica gel,100-200 mesh,10% ethyl acetate in petroleum ether) to obtain methyl 3-amino-5-chloropyrazine-2-carboxylate (940 mg,15.4% yield).
References:
GENENTECH, INC.;F. HOFFMANN-LA ROCHE AG;KOEHLER, Michael Friedrich Thomas;SMITH, Peter Andrew;WINTER, Dana;SOW, Boubacar;STURINO, Claudio;PELLETIER, Guillaume;BOUDREAULT, Jonathan WO2020/243155, 2020, A1 Location in patent:Paragraph 00204-00205
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1458-03-3
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$10.00/100mg
28643-16-5
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1503-03-3
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$45.00/10mg
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16298-03-6
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$7.00/1g
28643-16-5
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