ChemicalBook CAS DataBase List Sulfadimethoxine

Sulfadimethoxine synthesis

4synthesis methods

Product Name:Sulfadimethoxine
CAS Number:122-11-2
Molecular formula:C12H14N4O4S
Molecular Weight:310.33

555-25-9 Synthesis

4-(Acetylamino)-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide

555-25-9
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122-11-2
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Yield:122-11-2 96%

Reaction Conditions:

with methanol;sodium hydroxide at 85; for 6 h;Large scale;Temperature;

Steps:

1.2 Example 1

(2), in 2000L reactor was added 600kg of methanol, condensation product 348.5kg, 20% caustic soda 440kg,Stir the temperature to 85 ° C and reflux for 6h. After tracking the reaction is completed, cooled to below 10 ,A 20% hydrochloric acid solution was added dropwise until PH = 6.7.After cooling to 0 ° C for centrifugation, the crude sulfathiazine-2,6-dimethoxypyrimidine (SDM) was obtained.In the crude product by adding methanol 800kg, activated carbon 15kg, heated to reflux 0.5h, while hot pressure filtration,The filtrate was cooled to 0 ° C, centrifuged and dried to give 294.6 kg of product (SDM) in 96% yield,Purity is 99%.

References:

CN107325057,2017,A Location in patent:Paragraph 0027; 0028; 0035; 0036; 0040; 0041; 0045; 0046