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ChemicalBook CAS DataBase List Sodium deoxycholate
302-95-4

Sodium deoxycholate synthesis

5synthesis methods
-

Yield:302-95-4 100%

Reaction Conditions:

with sodium hydroxide in methanol;lithium hydroxide monohydrate at 25;

Steps:

3.8; 6.8 Step 8:

Deoxycholic acid (1.30g, 3.3mmol, 1.0eq.) was added to a 100mL single-neck bottle,Add anhydrous methanol (20 mL) to dissolve, add an aqueous solution of sodium hydroxide (132.0 mg, 3.3 mmol, 1.0 eq.), stir at 25 ° C for 15-20 h, concentrate under reduced pressure to remove the solvent,Then, 2.6 ml of methanol and 20.8 ml of acetone were added to the reaction solution, and concentrated under reduced pressure.Drying gave sodium deoxycholate as a white solid (1.37 g, 100% yield).

References:

CN114716497,2022,A Location in patent:Paragraph 0139-0140; 0157-0158; 0180-0181; 0198-0199

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