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144391-74-2

SalMeterol iMpurity synthesis

5synthesis methods
Methanone, phenyl(2-phenyl-1-pyrrolidinyl)-

98528-33-7
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SalMeterol iMpurity

144391-74-2
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Yield:144391-74-2 84 %

Reaction Conditions:

Stage #1: phenyl(2-phenylpyrrolidin-1-yl)methanonewith tris(pentafluorophenyl)borate;phenylsilane at 120;Sealed tube;
Stage #2: with hydrogenchloride in diethyl ether at 20;regioselective reaction;

References:

Peng, Yi;Oestreich, Martin [Chemistry - A European Journal,2023,vol. 29,# 13,art. no. E202203721] Location in patent:supporting information

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