Yield:1026661-43-7 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;dichloromethane at 0 - 20; for 20 h;

Steps:

1.B

1(B) (S)-Piperidine-3-carboxylic acid amide hydrochloride; To a solution of (S)-3-carbamoyl-piperidine-l-carboxylic acid tert-butyl ester (2 g, 8.77 mmol), in dichloromethane (20 mL), 9 mL of 4N HCl (dioxane solution) were added at O⁰C and the reaction mixture was allowed to warm at room temperature and stirred for 20 h. The solvent was evaporated under reduced pressure to give the title compound as a white solid, which was used for the next step without further purification. Yield: quantitative; LCMS (RT): 0.76 min (Method C); MS (ES+) gave m/z: 128.9.

References:

WO2008/56259,2008,A2 Location in patent:Page/Page column 17