(R)-2-Hydroxymethylbutanoic acid synthesis
1synthesis methods
- Product Name:(R)-2-Hydroxymethylbutanoic acid
- CAS Number:72604-79-6
- Molecular formula:C5H10O3
- Molecular Weight:118.13
Yield:72604-79-6 40%
Reaction Conditions:
Stage #1: formaldehyd;2-aminopentanoic acidwith ketopantoate hydroxymethyltransferase;cobalt(II) chloride at 20; pH=7.5; for 24 h;Enzymatic reaction;
Stage #2: with dihydrogen peroxide pH=7.5;
Stage #3: with catalase from bovine liver in aq. phosphate buffer; pH=7;Enzymatic reaction;enantioselective reaction;
References:
Pickl, Mathias;Marín-Valls, Roser;Joglar, Jesús;Bujons, Jordi;Clapés, Pere [Advanced Synthesis and Catalysis,2021,vol. 363,# 11,p. 2866 - 2876]