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ChemicalBook CAS DataBase List (R)-1-Boc-2-Phenylpiperazine
886766-60-5

(R)-1-Boc-2-Phenylpiperazine synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: triethylamine / dichloromethane
2: sodium hydride / N,N-dimethyl-formamide
3: lithium aluminium tetrahydride / tetrahydrofuran / Reflux
4: palladium on activated charcoal; hydrogen / methanol

References:

Usui, Yoshihiro;Uehara, Fumiaki;Hiki, Shinsuke;Watanabe, Kazutoshi;Tanaka, Hiroshi;Shouda, Aya;Yokoshima, Satoshi;Aritomo, Keiichi;Adachi, Takashi;Fukunaga, Kenji;Sunada, Shinji;Nabeno, Mika;Saito, Ken-Ichi;Eguchi, Jun-ichi;Yamagami, Keiji;Asano, Shouichi;Tanaka, Shinji;Yuki, Satoshi;Yoshii, Narihiko;Fujimura, Masatake;Horikawa, Takashi [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 16,p. 3726 - 3732]

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