5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione synthesis
- Product Name:5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione
- CAS Number:4664-00-0
- Molecular formula:C7H4N2O2
- Molecular Weight:148.12
89-00-9
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$5.00/5g
4664-00-0
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$15.00/1g
Yield:4664-00-0 84%
Reaction Conditions:
with ammonium hydroxide at 140; for 6 h;Reagent/catalyst;
Steps:
9 Preparation of pyrrolo[3,4-b]pyridine-5,7-dione
To 1000 ml three-necked flask were added 167 g of 2,3-pyridinedicarboxylic acid (1.0 mol) and 300 ml of concentrated aqueous ammonia (28%), followed by stirring under reflux for 6 hours at 140 °C, the liquid reaction mixture became dark brown, thin layer Analysis of the reaction was followed, when the starting material 2,3-pyridinedicarboxylic acid completion of the reaction, the reaction mixture was cooled to room temperature, under stirring, the reaction mixture was cooled as slowly pouredinto 500 ml of cold water, a large number of gray solid immediately precipitated, was filtered and the filter cake washed with coldwater and dried in vacuo overnight at 60 °C, to give a gray powder 125 g, yield 84%.
References:
Guo Feng;Guo, Feng CN102746294, 2016, B Location in patent:Paragraph 0077; 0078
699-98-9
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4664-00-0
120 suppliers
$15.00/1g
