ChemicalBook CAS DataBase List O-TOLUAMIDE

O-TOLUAMIDE synthesis

12synthesis methods

Product Name:O-TOLUAMIDE
CAS Number:527-85-5
Molecular formula:C8H9NO
Molecular Weight:135.16

529-20-4
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$5.00/5g

527-85-5
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$29.00/25g

Yield:527-85-5 96%

Reaction Conditions:

with hydroxylamine;C₃₃H₂₈F₃N₅O₃Ru⁽¹⁺⁾*Cl^(1-) in water at 60; for 0.5 h;Catalytic behavior;Sonication;

Steps:

A typical procedure for the one-pot conversion of aldehydes to amides
General procedure: A mixture of aldehyde (1.0 mmol) and hydroxylamine (1.0 mmol) in water (5.0mL) was prepared. The ensuing mixture and 0.1 mol% of Ru-complexes (5 or 9) were taken in a reaction vessel and sonicated at 60 oC for the appropriate time. Theprogress of the reaction was monitored by TLC analysis. After completion of thereaction, the reaction was cooled to room temperature and the solvent wasevaporated. The residue was suspended in ethyl acetate, filtered to remove thecatalyst and the solvent evaporated to obtain the desired product. The identity ofthe obtained amides was assessed by comparison of their NMR spectroscopic datawith those reported in the literature.

References:

Arafa, Wael Abdelgayed Ahmed [Bulletin of the Chemical Society of Japan,2020,vol. 93,# 9,p. 1056 - 1064] Location in patent:supporting information

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118-90-1 Synthesis