ChemicalBook CAS DataBase List N-Methylformamide

N-Methylformamide synthesis

10synthesis methods

Product Name:N-Methylformamide
CAS Number:123-39-7
Molecular formula:C2H5NO
Molecular Weight:59.07

N-Methylformamide (NMF) can be synthesized by: (1) reacting methylamine, carbon monoxide, methanol and a small amount of potassium acetate at 250 atm and 160°C; (2) heating methylamine with carbon monoxide and some sodium ethoxide in ethanol at 150 atm; (3) treating methylformate with methylamine and methanol; (4) reacting hexamethylenetetramine with formamide and hydrogen in the presence of Raney nickel at 130-145°C (Beilstein's Handbuch, 1977).

820-57-5 Synthesis

820-57-5
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74-89-5 Synthesis

74-89-5
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$13.44/25ML

123-39-7
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$5.00/25g

513-42-8
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$12.90/1g

Yield:513-42-8 1400 g ，123-39-7 1080 g

Reaction Conditions:

with aluminum oxide at 3 - 10;Large scale;

Steps:

3 Preparation of Methylallyl alcohol and N-methylformamide

into a 5L reaction flask, stirring, add 2000 g of methallyl formate, add 90 g of basic aluminiumoxide, cooled at 5° C. Slowly pass through methylamine gas, the reaction temperature is controlled at about 3-10 ° C. pass through about 350g methylamine , gas phase detection of methallyl basic consumption. Stop the reaction. Atmospheric distillation to collect 114 ° C fraction, that is Methylallyl alcohol 1400g. Decompression distillation and then collected 1080g of N-methyl formamide fraction.

References:

CN107324974,2017,A Location in patent:Paragraph 0026-0027

201230-82-2 Synthesis