ChemicalBook CAS DataBase List METHYL TRIPHENYLMETHYL ETHER

METHYL TRIPHENYLMETHYL ETHER synthesis

13synthesis methods

Product Name:METHYL TRIPHENYLMETHYL ETHER
CAS Number:596-31-6
Molecular formula:C20H18O
Molecular Weight:274.36

76-84-6 Synthesis

76-84-6
422 suppliers
$6.00/25g

74-88-4
348 suppliers
$15.00/10g

596-31-6
79 suppliers
$110.00/100mg

Yield: 71%

Reaction Conditions:

with sodium hydride in tetrahydrofuran;mineral oil at 20; for 15 h;

Steps:

3.1.9. 2-Phenyl-2-methoxypropane (6a)
General procedure: To a solution of 2-phenyl-2-propanol (1c) (1.413 g,10.4 mmol) inTHF (20 mL) was added NaH (60 wt% oil dispersion) (1.422 g,35.6 mmol) and MeI (4.755 g, 33.5 mmol) at room temperature, andthe mixture was stirred for 15 h at that temperature. To the reactionmixture was added H2O (30 mL). After being extracted with EtOAc(30 mL 3), the organic layer was dried with MgSO4. After theconcentration, the residue was subject to column chromatographyon SiO2 (hexane: EtOAc 9: 1) to give 2-phenyl-2-methoxypropane (0.850 g, 5.66 mmol, 54%) as colorless oil.

References:

Matsumoto, Shoji;Naito, Masafumi;Oseki, Takehisa;Akazome, Motohiro;Otani, Yasuhiko [Tetrahedron,2017,vol. 73,# 52,p. 7254 - 7259]