Methyl benzenesulfonate synthesis
- Product Name:Methyl benzenesulfonate
- CAS Number:80-18-2
- Molecular formula:C7H8O3S
- Molecular Weight:172.2
Yield:80-18-2 44%
Reaction Conditions:
in neat (no solvent) at 95; for 8 h;Inert atmosphere;
Steps:
General Procedure A for the Preparation of Sulfonic esters.
General procedure: A mixture of arene/heteroarene (0.01 mol) and alkyl sulfate 2 (0.03 mol) was stirred at 95°C under nitrogen atmosphere until the consumption of the starting material as monitored by TLC was complete. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate (20 mL) and washed with water (20 mL), and aq.ammonia solution (20 mL 2). The organic layer was dried over anhydrous sodium sulfate, solvent was removed under reduced pressure, and then purified through silica gel column chromatography to give the corresponding sulfonic esters.
References:
Bhatthula, Bharath Kumar Goud;Kanchani, Janardhan Reddy;Arava, Veera Reddy;Marata Chenna Subbarao, Subha [Synthetic Communications,2020,p. 1 - 16] Location in patent:supporting information