ChemicalBook CAS DataBase List Methyl 6-aminonicotinate

Methyl 6-aminonicotinate synthesis

7synthesis methods

Product Name:Methyl 6-aminonicotinate
CAS Number:36052-24-1
Molecular formula:C7H8N2O2
Molecular Weight:152.15

67-56-1 Synthesis

67-56-1
752 suppliers
$7.29/5ml-f

3167-49-5 Synthesis

3167-49-5
387 suppliers
$8.00/5g

36052-24-1
256 suppliers
$10.00/1g

Yield:36052-24-1 89%

Reaction Conditions:

with thionyl chloride at 80; for 12 h;Inert atmosphere;

Steps:

Step a
General procedure: A mixture of 4-aminobenzoic acid (32-34, 5.0 mmol), thionyl chloride(1.487 g, 5.0 mmol), and MeOH (20.0 mL) was flushed with argon, and stirred at80°C for 12 hours. Remove reaction solvent by rota vapor. The reaction mixture wasneutralized with NaHCO3(sat) (20.0 mL) and extracted with ethyl acetate (100 mL ×3). The combined organic extracts were washed with brine, dried by Na2SO4, filtered,and evaporated, to get cmopound 35-37 (63-89%) as a white solid.

References:

Hsieh, Hao-Yu;Chuang, Hsiao-Ching;Shen, Fang-Hsiu;Detroja, Kinjal;Hsin, Ling-Wei;Chen, Ching-Shih [European Journal of Medicinal Chemistry,2017,vol. 140,p. 42 - 51] Location in patent:supporting information

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3167-49-5 Synthesis

3167-49-5
387 suppliers
$8.00/5g