methyl 5-bromo-2-methoxybenzoate synthesis
- Product Name:methyl 5-bromo-2-methoxybenzoate
- CAS Number:7120-41-4
- Molecular formula:C9H9BrO3
- Molecular Weight:245.07
2476-35-9
144 suppliers
$8.00/1g
18107-18-1
209 suppliers
$33.00/5g
7120-41-4
68 suppliers
$45.00/100mg
Yield: 99%
Reaction Conditions:
in Petroleum ether
Steps:
158.1 Step 1:
Step 1:
Methyl 5-bromo-2-methoxybenzoate
Trimethylsilyldiazomethane (2 M solution in hexane, 40 mL, 80.0 mmol) was added to a solution of 5-bromo-2-methoxybenzoic acid (5.00 g, 21.6 mmol) in methanol (100 mL) at 0° C., and the resulting solution was stirred at room temperature for 4 h.
The reaction mixture was evaporated in vacuo and the residue was purified via flash chromatography on silica gel (solvent gradient: 0-20% ethyl acetate in petroleum ether) to yield 5.26 g (99%) of the title compound as a white solid. 1H NMR (300 MHz, CDCl3) δ 7.91 (s, 1H), 7.58-7.54 (d, J=9.0 Hz, 1H), 6.87 (d, J=9.0 Hz, 1H), 3.90 (s, 6H).
References:
Genentech, Inc.;Braun, Marie-Gabrielle;Garland, Keira;Hanan, Emily;Purkey, Hans;Staben, Steven T.;Heald, Robert Andrew;Knight, Jamie;Macleod, Calum;Lu, Aijun;Wu, Guosheng;Yeap, Siew Kuen US2018/65983, 2018, A1
606-45-1
255 suppliers
$9.00/10g
7120-41-4
68 suppliers
$45.00/100mg
67-56-1
746 suppliers
$7.29/5ml-f
2476-35-9
144 suppliers
$8.00/1g
7120-41-4
68 suppliers
$45.00/100mg
